Learning speed and detection sensitivity controlled by distinct cortico-fugal neurons in visual cortex.
behavior
cortex
cortico-fugal pathways
mouse
neuroscience
striatum
superior colliculus
vision
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
07 12 2020
07 12 2020
Historique:
received:
23
05
2020
accepted:
06
12
2020
pubmed:
8
12
2020
medline:
23
3
2021
entrez:
7
12
2020
Statut:
epublish
Résumé
Vertebrates can change their behavior upon detection of visual stimuli according to the outcome their actions produce. Such goal-directed behavior involves evolutionary conserved brain structures like the striatum and optic tectum, which receive ascending visual input from the periphery. In mammals, however, these structures also receive descending visual input from visual cortex (VC), via neurons that give rise to cortico-fugal projections. The function of cortico-fugal neurons in visually guided, goal-directed behavior remains unclear. Here, we address the impact of two populations of cortico-fugal neurons in mouse VC in the learning and performance of a visual detection task. We show that the ablation of striatal projecting neurons reduces learning speed, whereas the ablation of superior colliculus projecting neurons does not impact learning but reduces detection sensitivity. This functional dissociation between distinct cortico-fugal neurons in controlling learning speed and detection sensitivity suggests an adaptive contribution of cortico-fugal pathways even in simple goal-directed behavior.
Identifiants
pubmed: 33284107
doi: 10.7554/eLife.59247
pii: 59247
pmc: PMC7748414
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NEI NIH HHS
ID : R01 EY025668
Pays : United States
Organisme : European Molecular Biology Organization
ID : ALTF741-2012
Pays : International
Organisme : Swiss National Science Foundation
ID : 151168
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 138719
Pays : Switzerland
Informations de copyright
© 2020, Ruediger and Scanziani.
Déclaration de conflit d'intérêts
SR, MS No competing interests declared
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