Determination of antiretroviral drugs for buyers' club in Switzerland using capillary electrophoresis methods.
Antiretroviral drugs
Buyers’ club
CE
Journal
Electrophoresis
ISSN: 1522-2683
Titre abrégé: Electrophoresis
Pays: Germany
ID NLM: 8204476
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
27
07
2020
revised:
06
11
2020
accepted:
01
12
2020
pubmed:
8
12
2020
medline:
24
12
2021
entrez:
7
12
2020
Statut:
ppublish
Résumé
Human immunodeficiency virus-acquired immunodeficiency syndrome continues to be a major global public health issue, having claimed almost 33 million lives to date. Due to the high cost of antiretroviral treatment, access to these drugs remains difficult for vulnerable populations, such as migrants and people living in prisons, who often do not have health insurance. These factors lead to poorer health outcomes and higher transmission rates. The personal importation scheme for unapproved generics from foreign countries is one option to access affordable human immunodeficiency virus treatment. However, the risk of importing falsified medicine remains high, and the quality control of unapproved drugs is lacking. In this context, three CE methods for the analysis of nine antiviral drugs found in commercial pharmaceutical formulations were evaluated. The selected compounds were emtricitabine, tenofovir disoproxil, tenofovir alafenamide, rilpivirine, efavirenz, raltegravir, dolutegravir, abacavir, and lamivudine. The developed methods were successfully applied to determine the active pharmaceutical ingredients of commercial formulations and unapproved generics. The quality control of unapproved generics by CE is an attractive approach due to its good standard of quality, low cost, ecofriendliness, and ease of implementation.
Identifiants
pubmed: 33284492
doi: 10.1002/elps.202000216
doi:
Substances chimiques
Anti-Retroviral Agents
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
708-718Informations de copyright
© 2020 Wiley-VCH GmbH.
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