Inpatient COVID-19 outcomes in solid organ transplant recipients compared to non-solid organ transplant patients: A retrospective cohort.
clinical research / practice
complication: infectious
infection and infectious agents - viral
infectious disease
organ transplantation in general
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
01
11
2020
received:
15
09
2020
accepted:
22
11
2020
pubmed:
8
12
2020
medline:
6
7
2021
entrez:
7
12
2020
Statut:
ppublish
Résumé
Immunosuppression and comorbidities might place solid organ transplant (SOT) recipients at higher risk from COVID-19, as suggested by recent case series. We compared 45 SOT vs. 2427 non-SOT patients who were admitted with COVID-19 to our health-care system (March 1, 2020 - August 21, 2020), evaluating hospital length-of-stay and inpatient mortality using competing-risks regression. We compared trajectories of WHO COVID-19 severity scale using mixed-effects ordinal logistic regression, adjusting for severity score at admission. SOT and non-SOT patients had comparable age, sex, and race, but SOT recipients were more likely to have diabetes (60% vs. 34%, p < .001), hypertension (69% vs. 44%, p = .001), HIV (7% vs. 1.4%, p = .024), and peripheral vascular disorders (19% vs. 8%, p = .018). There were no statistically significant differences between SOT and non-SOT in maximum illness severity score (p = .13), length-of-stay (sHR:
Identifiants
pubmed: 33284498
doi: 10.1111/ajt.16431
pmc: PMC9800757
pii: S1600-6135(22)08637-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2498-2508Subventions
Organisme : NIDDK NIH HHS
ID : K01 DK101677
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24 DK101828
Pays : United States
Organisme : NIDDK NIH HHS
ID : K24DK101828
Pays : United States
Organisme : NIDDK NIH HHS
ID : K01DK101677
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The American Society of Transplantation and the American Society of Transplant Surgeons.
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