Screening for infantile hepatic hemangioma in patients with cutaneous infantile hemangioma: A multicenter prospective study.
cutoff point
infantile hemangioma
infantile hepatic hemangioma
multiple
screening
Journal
Journal of the American Academy of Dermatology
ISSN: 1097-6787
Titre abrégé: J Am Acad Dermatol
Pays: United States
ID NLM: 7907132
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
09
06
2020
revised:
12
10
2020
accepted:
19
11
2020
pubmed:
8
12
2020
medline:
26
8
2021
entrez:
7
12
2020
Statut:
ppublish
Résumé
Abdominal ultrasonography has been proposed to screen for infantile hepatic hemangioma (IHH) in patients with multiple cutaneous infantile hemangiomas (IHs). The aim of this study was to establish the optimal cutoff point for the number of cutaneous IHs needed to screen for IHH. We performed a prospective, multicenter study to screen for IHH in patients younger than 9 months who had multiple cutaneous IHs (n ≥ 3) on ultrasonography. For comparison, a group of patients with 1 or 2 focal cutaneous IHs was also recruited. In total, 676 patients with at least 3 cutaneous IHs and 980 patients with 1 or 2 focal cutaneous IHs were enrolled. Thirty-one patients were found to have IHH. A higher number of cutaneous IHs was associated with an increased risk of IHH (R = 0.973; P < .001). Receiver operating characteristic curve analysis showed that 5 cutaneous IHs was the optimal cutoff point to screen for IHH, with an area under the curve of 0.872 (P < .001; 95% confidence interval, 0.789-0.955). This was an uncontrolled study. Screening for IHH is recommended in patients younger than 9 months who present with 5 or more cutaneous IHs.
Sections du résumé
BACKGROUND
BACKGROUND
Abdominal ultrasonography has been proposed to screen for infantile hepatic hemangioma (IHH) in patients with multiple cutaneous infantile hemangiomas (IHs).
OBJECTIVES
OBJECTIVE
The aim of this study was to establish the optimal cutoff point for the number of cutaneous IHs needed to screen for IHH.
METHODS
METHODS
We performed a prospective, multicenter study to screen for IHH in patients younger than 9 months who had multiple cutaneous IHs (n ≥ 3) on ultrasonography. For comparison, a group of patients with 1 or 2 focal cutaneous IHs was also recruited.
RESULTS
RESULTS
In total, 676 patients with at least 3 cutaneous IHs and 980 patients with 1 or 2 focal cutaneous IHs were enrolled. Thirty-one patients were found to have IHH. A higher number of cutaneous IHs was associated with an increased risk of IHH (R = 0.973; P < .001). Receiver operating characteristic curve analysis showed that 5 cutaneous IHs was the optimal cutoff point to screen for IHH, with an area under the curve of 0.872 (P < .001; 95% confidence interval, 0.789-0.955).
LIMITATIONS
CONCLUSIONS
This was an uncontrolled study.
CONCLUSIONS
CONCLUSIONS
Screening for IHH is recommended in patients younger than 9 months who present with 5 or more cutaneous IHs.
Identifiants
pubmed: 33285272
pii: S0190-9622(20)33116-9
doi: 10.1016/j.jaad.2020.11.062
pii:
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1378-1384Informations de copyright
Copyright © 2020 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of interest None disclosed.