Towards a comprehensive view of 8-oxo-7,8-dihydro-2'-deoxyguanosine: Highlighting the intertwined roles of DNA damage and epigenetics in genomic instability.
8-oxodG
Base excision repair
Cancer
Double-strand break
Genome instability
Single-Strand break
TOP1-DPC
Journal
DNA repair
ISSN: 1568-7856
Titre abrégé: DNA Repair (Amst)
Pays: Netherlands
ID NLM: 101139138
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
12
11
2020
accepted:
16
11
2020
pubmed:
8
12
2020
medline:
10
8
2021
entrez:
7
12
2020
Statut:
ppublish
Résumé
8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a major product of DNA oxidation, is a pre-mutagenic lesion which is prone to mispair, if left unrepaired, with 2'-deoxyadenosine during DNA replication. While unrepaired or incompletely repaired 8-oxodG has classically been associated with genome instability and cancer, it has recently been reported to have a role in the epigenetic regulation of gene expression. Despite the growing collection of genome-wide 8-oxodG mapping studies that have been used to provide new insight on the functional nature of 8-oxodG within the genome, a comprehensive view that brings together the epigenetic and the mutagenic nature of the 8-oxodG is still lacking. To help address this gap, this review aims to provide (i) a description of the state-of-the-art knowledge on both the mutagenic and epigenetic roles of 8-oxodG; (ii) putative molecular models through which the 8-oxodG can cause genome instability; (iii) a possible molecular model on how 8-oxodG, acting as an epigenetic signal, could cause the translocations and deletions which are associated with cancer.
Identifiants
pubmed: 33285475
pii: S1568-7864(20)30287-1
doi: 10.1016/j.dnarep.2020.103027
pmc: PMC7926032
mid: NIHMS1669495
pii:
doi:
Substances chimiques
8-Hydroxy-2'-Deoxyguanosine
88847-89-6
DNA
9007-49-2
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
103027Subventions
Organisme : NIEHS NIH HHS
ID : R15 ES027196
Pays : United States
Organisme : NIEHS NIH HHS
ID : R41 ES030274
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.
Références
DNA Repair (Amst). 2013 Sep;12(9):733-40
pubmed: 23830898
Cell Cycle. 2004 Aug;3(8):998-1001
pubmed: 15280658
J Biol Chem. 2002 Mar 29;277(13):11135-42
pubmed: 11801590
Nucleic Acids Res. 2020 May 7;48(8):4309-4324
pubmed: 32198884
Mol Carcinog. 2017 Feb;56(2):781-788
pubmed: 27253753
Mol Aspects Med. 2016 Feb-Mar;47-48:76-89
pubmed: 26776678
Mol Clin Oncol. 2017 Feb;6(2):139-153
pubmed: 28357082
Oncogene. 2004 Aug 12;23(36):6040-6
pubmed: 15195142
Front Genet. 2013 Feb 28;4:18
pubmed: 23450852
Nat Genet. 2013 May;45(5):478-86
pubmed: 23525077
Nucleic Acids Res. 2020 Feb 28;48(4):1925-1940
pubmed: 31828326
Nature. 2004 Sep 9;431(7005):217-21
pubmed: 15322558
J Am Chem Soc. 2017 Feb 22;139(7):2569-2572
pubmed: 28150947
Nature. 2007 Mar 8;446(7132):153-8
pubmed: 17344846
DNA Repair (Amst). 2007 Apr 1;6(4):398-409
pubmed: 17129767
DNA Repair (Amst). 2014 Mar;15:11-20
pubmed: 24559511
Mol Cell. 2013 May 9;50(3):309-21
pubmed: 23664375
DNA Repair (Amst). 2010 Jun 4;9(6):604-16
pubmed: 20399712
PLoS Genet. 2012;8(11):e1003052
pubmed: 23144635
Antioxid Redox Signal. 2011 Jun 15;14(12):2491-507
pubmed: 20649466
Nat Rev Mol Cell Biol. 2007 Sep;8(9):722-8
pubmed: 17700625
Dev Biol. 1999 Apr 15;208(2):513-29
pubmed: 10191063
Chem Res Toxicol. 2019 Mar 18;32(3):437-446
pubmed: 30604962
Genes Environ. 2016 Dec 1;39:2
pubmed: 27980700
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61
pubmed: 10725358
Nucleic Acids Res. 2015 Sep 18;43(16):8089-99
pubmed: 26220180
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
J Am Chem Soc. 2019 Jul 17;141(28):11036-11049
pubmed: 31241930
EMBO J. 2009 Oct 21;28(20):3207-15
pubmed: 19713937
Mutat Res. 2009 Mar 31;674(1-2):36-44
pubmed: 18977455
Nature. 2000 Feb 24;403(6772):859-66
pubmed: 10706276
Curr Biol. 2002 Jun 4;12(11):912-8
pubmed: 12062055
Mol Cell Biol. 2006 May;26(10):3935-41
pubmed: 16648486
Biochim Biophys Acta. 2016 Apr;1859(4):663-74
pubmed: 26855080
Oncogene. 2002 Apr 4;21(15):2320-7
pubmed: 11948415
Antioxid Redox Signal. 2011 Sep 15;15(6):1583-606
pubmed: 21473702
Cancer Discov. 2015 Aug;5(8):821-831
pubmed: 26003801
Proc Natl Acad Sci U S A. 2007 Aug 21;104(34):13535-6
pubmed: 17699620
J Biol Chem. 1999 Mar 26;274(13):8516-23
pubmed: 10085084
Cell. 2004 Dec 29;119(7):941-53
pubmed: 15620353
Mol Cell. 2010 Jul 30;39(2):222-33
pubmed: 20670891
Redox Biol. 2020 Jan;29:101398
pubmed: 31926624
Redox Biol. 2019 Jul;25:101084
pubmed: 30612957
Cell Res. 2008 Jan;18(1):73-84
pubmed: 18166977
Nature. 2010 Jan 14;463(7278):191-6
pubmed: 20016485
Annu Rev Biochem. 2017 Jun 20;86:715-748
pubmed: 28441057
Nucleic Acids Res. 2019 Jan 10;47(1):221-236
pubmed: 30462294
Int J Mol Sci. 2017 Jun 14;18(6):
pubmed: 28613231
Exp Neurobiol. 2015 Dec;24(4):325-40
pubmed: 26713080
Nucleosides Nucleotides Nucleic Acids. 2013;32(3):124-36
pubmed: 23473100
J Biol Chem. 2003 Dec 12;278(50):49679-84
pubmed: 14522990
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5
pubmed: 10557315
Oxid Med Cell Longev. 2016;2016:1245049
pubmed: 27478531
Mol Cell Biol. 2001 Dec;21(24):8437-51
pubmed: 11713279
Arch Biochem Biophys. 2017 Mar 1;617:101-105
pubmed: 27665998
Cell. 2017 Feb 9;168(4):644-656
pubmed: 28187286
Curr Biol. 2014 May 19;24(10):R453-62
pubmed: 24845678
Annu Rev Biochem. 2013;82:139-70
pubmed: 23495937
Br J Cancer. 2010 Mar 16;102(6):1018-23
pubmed: 20179711
DNA Repair (Amst). 2016 Aug;44:178-185
pubmed: 27324272
Cold Spring Harb Symp Quant Biol. 2000;65:127-33
pubmed: 12760027
Proc Natl Acad Sci U S A. 2020 Sep 8;117(36):22183-22192
pubmed: 32826329
Sci Rep. 2017 Mar 07;7:43297
pubmed: 28266569
Int J Mol Sci. 2017 Aug 18;18(8):
pubmed: 28820464
Proc Natl Acad Sci U S A. 2020 May 26;117(21):11409-11420
pubmed: 32404420
Nat Rev Cancer. 2012 Dec;12(12):801-17
pubmed: 23175119
DNA Res. 2014 Dec;21(6):603-12
pubmed: 25008760
Science. 2008 Jan 11;319(5860):202-6
pubmed: 18187655
Oncogene. 2010 Jun 24;29(25):3691-702
pubmed: 20418916
Nucleic Acids Res. 2020 Sep 18;48(16):8943-8958
pubmed: 32697292
Proc Soc Exp Biol Med. 1999 Dec;222(3):246-52
pubmed: 10601883
Nucleic Acids Res. 2016 Apr 20;44(7):3165-75
pubmed: 26773055
J Am Chem Soc. 2009 Jul 15;131(27):9506-15
pubmed: 19537786
Annu Rev Microbiol. 2005;59:357-77
pubmed: 16153173
Bioessays. 2004 May;26(5):533-42
pubmed: 15112233
Nat Chem. 2019 Jul;11(7):629-637
pubmed: 31209299
DNA Repair (Amst). 2006 Dec 9;5(12):1439-48
pubmed: 16982218
Oxid Med Cell Longev. 2016;2016:3565127
pubmed: 27247702
ACS Chem Biol. 2017 Sep 15;12(9):2417-2426
pubmed: 28829124
Bioessays. 2001 May;23(5):447-55
pubmed: 11340626
Nucleic Acids Res. 2007;35(12):4103-13
pubmed: 17567611
Nature. 2009 Oct 22;461(7267):1071-8
pubmed: 19847258
Cell Cycle. 2010 Aug 1;9(15):3002-4
pubmed: 20714214
Oxid Med Cell Longev. 2018 Mar 27;2018:2389523
pubmed: 29770165
Nat Struct Mol Biol. 2010 Jul;17(7):889-90
pubmed: 20526335
Free Radic Biol Med. 2007 Dec 15;43(12):1616-26
pubmed: 18037127
Nat Genet. 1996 Aug;13(4):489-91
pubmed: 8696349
Biochemistry. 2020 Jan 14;59(1):85-89
pubmed: 31618020
J Biol Chem. 2001 Feb 23;276(8):5547-55
pubmed: 11092888
Physiol Rev. 1998 Apr;78(2):547-81
pubmed: 9562038
N Engl J Med. 2009 Oct 8;361(15):1475-85
pubmed: 19812404
Mutat Res. 1990 May;238(3):305-11
pubmed: 1692969
NPJ Precis Oncol. 2017;1:
pubmed: 28825044
Nature. 2010 Jan 14;463(7278):184-90
pubmed: 20016488
Genome Biol. 2018 Jul 30;19(1):100
pubmed: 30060749
Nucleic Acids Res. 2001 Feb 1;29(3):743-52
pubmed: 11160897
Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11534-9
pubmed: 8876170
DNA Repair (Amst). 2020 May;89:102837
pubmed: 32200233
Cell Res. 2008 Jan;18(1):85-98
pubmed: 18157157
Nucleic Acids Res. 2018 Jan 25;46(2):661-676
pubmed: 29165690
EMBO J. 1997 Jun 2;16(11):3341-8
pubmed: 9214649
Hum Pathol. 2016 Jun;52:145-52
pubmed: 26980051
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8919-23
pubmed: 8799128
Free Radic Biol Med. 2007 May 15;42(10):1552-60
pubmed: 17448902
J Mol Biol. 2002 Feb 1;315(5):1039-47
pubmed: 11827474
Nature. 2007 May 31;447(7144):606-8
pubmed: 17507928
Nucleic Acids Res. 2008 Mar;36(5):1555-66
pubmed: 18208837
Genes Cells. 2005 Dec;10(12):1139-51
pubmed: 16324151
J Bioenerg Biomembr. 1997 Feb;29(1):89-95
pubmed: 9067806
Cell Rep. 2019 Sep 17;28(12):3167-3181.e6
pubmed: 31533039
Nat Chem Biol. 2008 May;4(5):278-86
pubmed: 18421291
DNA Cell Biol. 2017 Aug;36(8):693-708
pubmed: 28598207
DNA Repair (Amst). 2009 May 1;8(5):637-42
pubmed: 19179121
J Biol Chem. 1998 May 1;273(18):11069-74
pubmed: 9556591
Nucleic Acids Res. 2005 Jan 12;33(1):298-306
pubmed: 15647512
Proc Natl Acad Sci U S A. 1987 May;84(10):3185-8
pubmed: 3033639
Mutat Res. 2004 Sep;567(1):1-61
pubmed: 15341901
Trends Biochem Sci. 2008 Apr;33(4):181-9
pubmed: 18343668
Oncogenesis. 2014 Oct 13;3:e121
pubmed: 25310643
Nat Genet. 2015 Sep;47(9):1038-1046
pubmed: 26192915
Nature. 1996 Jan 11;379(6561):183-6
pubmed: 8538772
Biochem J. 2013 Dec 15;456(3):337-46
pubmed: 24044889
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39
pubmed: 19412858
Annu Rev Plant Biol. 2008;59:143-66
pubmed: 18444899
Biochim Biophys Acta. 2013 Oct;1829(10):981-6
pubmed: 23684752
Nature. 1991 Jan 31;349(6308):431-4
pubmed: 1992344
Nature. 1992 Jan 16;355(6357):273-5
pubmed: 1309939
Comput Struct Biotechnol J. 2020 Jan 07;18:207-219
pubmed: 31993111
PLoS One. 2011;6(9):e24421
pubmed: 21931711
J Biol Chem. 1996 Apr 19;271(16):9573-8
pubmed: 8621631
J Biol Chem. 2016 Dec 2;291(49):25553-25566
pubmed: 27756845
J Biol Chem. 1999 May 21;274(21):15230-6
pubmed: 10329732
Cancers (Basel). 2019 Mar 07;11(3):
pubmed: 30866496
Mutat Res. 1998 Oct 21;409(1):17-29
pubmed: 9806499
Mol Cell. 2008 Feb 29;29(4):477-87
pubmed: 18313385
Cancer Sci. 2011 Apr;102(4):677-82
pubmed: 21235684
EMBO J. 2006 Sep 20;25(18):4305-15
pubmed: 16957781
Free Radic Biol Med. 2017 Jun;107:179-201
pubmed: 27903453
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2604-2609
pubmed: 28143930
ACS Chem Biol. 2018 Sep 21;13(9):2577-2584
pubmed: 30063821
Nat Commun. 2014 Mar 19;5:3446
pubmed: 24647101
J Biol Chem. 2012 Jul 6;287(28):23830-9
pubmed: 22577134
Cancer Res. 2003 Mar 1;63(5):902-5
pubmed: 12615700
Cell Res. 2008 Jan;18(1):48-63
pubmed: 18166976
Nucleic Acids Res. 2020 Jul 9;48(12):6715-6725
pubmed: 32484547
J Biol Inorg Chem. 2011 Oct;16(7):1067-78
pubmed: 21647776
DNA Repair (Amst). 2017 Nov;59:82-105
pubmed: 28963982
Annu Rev Pharmacol Toxicol. 2004;44:239-67
pubmed: 14744246
Oncotarget. 2016 May 3;7(18):25377-90
pubmed: 27015367
Nucleic Acids Res. 2015 Apr 20;43(7):3667-79
pubmed: 25800737
Nucleic Acids Res. 2014;42(17):11040-55
pubmed: 25217584
Semin Cancer Biol. 2010 Oct;20(5):320-8
pubmed: 20955798
Cancer Res. 2004 May 1;64(9):3096-102
pubmed: 15126346
Genome Biol. 2018 Dec 7;19(1):215
pubmed: 30526646
Nat Commun. 2016 Jan 29;7:10399
pubmed: 26822533
Cell Mol Life Sci. 2018 Oct;75(20):3741-3750
pubmed: 30043138
Genome Res. 2006 May;16(5):567-75
pubmed: 16651663
PLoS One. 2013;8(2):e56592
pubmed: 23451058
J Cell Sci. 2002 May 15;115(Pt 10):2165-77
pubmed: 11973357
Nucleic Acids Res. 2012 May;40(10):4247-60
pubmed: 22287629
DNA Repair (Amst). 2020 Oct;94:102926
pubmed: 32674013
Free Radic Biol Med. 2008 Sep 1;45(5):549-61
pubmed: 18544350
DNA Repair (Amst). 2017 Aug;56:75-83
pubmed: 28629775
Oncogene. 2007 Jun 28;26(30):4336-43
pubmed: 17297471
J Am Chem Soc. 2018 Aug 8;140(31):9783-9787
pubmed: 29944356
DNA Repair (Amst). 2005 May 2;4(5):583-93
pubmed: 15811630
Hum Exp Toxicol. 2012 Oct;31(10):981-1005
pubmed: 23023028
DNA Repair (Amst). 2015 Jul;31:73-9
pubmed: 26011397
FASEB J. 2003 Jul;17(10):1195-214
pubmed: 12832285
Nature. 1993 Apr 22;362(6422):709-15
pubmed: 8469282
Cancer Res. 2007 Jul 15;67(14):6599-604
pubmed: 17638869