Tissue quantification of radioiodine thyroid uptake in humans by an isotopic imaging technique on slides.
Iodine
imaging
iodine-131
radioactivity
thyroid tissue
Journal
Technology and health care : official journal of the European Society for Engineering and Medicine
ISSN: 1878-7401
Titre abrégé: Technol Health Care
Pays: Netherlands
ID NLM: 9314590
Informations de publication
Date de publication:
2021
2021
Historique:
pubmed:
9
12
2020
medline:
2
9
2021
entrez:
8
12
2020
Statut:
ppublish
Résumé
Thyroid metabolism involves iodine, which allows us to use radioactive iodine for diagnostic and therapy purposes. The efficiency of radioiodine therapy depends on several parameters; the ability of thyroid tissue to uptake radioactive iodine is one of them. The objective of this work is to quantify the radioactive iodine uptake on thyroid tissue. In this work, we developed a method to quantify the in vivo uptake of iodine-131 on sections of thyroid glands removed by thyroidectomies. We performed an analysis of histological sections of the thyroid tissue by beta imaging. We had the opportunity to quantify the fixed radioactivity and to analyze its distribution in the thyroid gland, thanks to the good spatial resolution available with the type of detector used. The results gave a high image resolution showing the heterogeneity of iodine-131 fixation by the thyroid tissue. We were able to quantify the tissue radioactivity in mega Becquerel (MBq) per volume unit. This work has shown that the direct quantification of the thyroid tissue uptake is possible using the beta imaging system.
Sections du résumé
BACKGROUND
BACKGROUND
Thyroid metabolism involves iodine, which allows us to use radioactive iodine for diagnostic and therapy purposes. The efficiency of radioiodine therapy depends on several parameters; the ability of thyroid tissue to uptake radioactive iodine is one of them.
OBJECTIVE
OBJECTIVE
The objective of this work is to quantify the radioactive iodine uptake on thyroid tissue.
METHODS
METHODS
In this work, we developed a method to quantify the in vivo uptake of iodine-131 on sections of thyroid glands removed by thyroidectomies. We performed an analysis of histological sections of the thyroid tissue by beta imaging. We had the opportunity to quantify the fixed radioactivity and to analyze its distribution in the thyroid gland, thanks to the good spatial resolution available with the type of detector used.
RESULTS
RESULTS
The results gave a high image resolution showing the heterogeneity of iodine-131 fixation by the thyroid tissue. We were able to quantify the tissue radioactivity in mega Becquerel (MBq) per volume unit.
CONCLUSION
CONCLUSIONS
This work has shown that the direct quantification of the thyroid tissue uptake is possible using the beta imaging system.
Identifiants
pubmed: 33285655
pii: THC202401
doi: 10.3233/THC-202401
doi:
Substances chimiques
Iodides
0
Iodine Radioisotopes
0
Iodine
9679TC07X4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM