Deficit in Adipose Differentiation in Mesenchymal Stem Cells Derived from Chronic Rhinosinusitis Nasal Polyps Compared to Nasal Mucosal Tissue.
Adipocytes
Adipogenesis
/ genetics
Apoptosis
Biomarkers
Biopsy
Cell Differentiation
Cell Proliferation
Chronic Disease
Disease Susceptibility
Humans
Immunophenotyping
Mesenchymal Stem Cells
/ cytology
Nasal Mucosa
/ metabolism
Nasal Polyps
/ etiology
Rhinitis
/ complications
Sinusitis
/ complications
adipocyte differentiation
apoptosis
mesenchymal cells
nasal polyps
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Dec 2020
03 Dec 2020
Historique:
received:
10
11
2020
revised:
28
11
2020
accepted:
01
12
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Chronic rhinosinusitis of the nasal mucosa is an inflammatory disease of paranasal sinuses, which causes rhinorrhea, nasal congestion, and hyposmia, and in some cases, it can result in the development of nasal polyposis. Nasal polyps are benign lobular-shaped growths that project in the nasal cavities; they originate from inflammation in the paranasal mucous membrane and are associated with a high expression of interleukins (IL)-4, IL-5, IL-13, and IgE. Polyps derive from the epithelial-mesenchymal transition of the nasal epithelium resulting in a nasal tissue remodeling. Nasal polyps from three patients with chronic rhinosinusitis as well as control non-polyp nasal mucosa were used to isolate and cultivate mesenchymal stem cells characterized as CD73
Identifiants
pubmed: 33287173
pii: ijms21239214
doi: 10.3390/ijms21239214
pmc: PMC7730671
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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