Timing of Development of Symptomatic Brain Metastases from Non-Small Cell Lung Cancer: Impact on Symptoms, Treatment, and Survival in the Era of Molecular Treatments.
brain metastasis
genetic mutations
metachronous
neurosurgery
precocious
radiosurgery
synchronous
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Dec 2020
03 Dec 2020
Historique:
received:
04
11
2020
revised:
26
11
2020
accepted:
28
11
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
9
12
2020
Statut:
epublish
Résumé
We attempted to analyze whether early presentation with brain metastases (BM) represents a poor prognostic factor in patients with non-small cell lung cancer (NSCLC), which should guide the treatment team towards less intensified therapy. In a retrospective bi-centric analysis, we identified patients receiving surgical treatment for NSCLC BM. We collected demographic-, tumor-, and treatment-related parameters and analyzed their influence on further survival. We included 377 patients. Development of BM was precocious in 99 (26.3%), synchronous in 152 (40.3%), and metachronous in 126 (33.4%) patients. The groups were comparable in terms of age ( Early BM presentation was not associated with worse OS in NSCLC BM patients.
Identifiants
pubmed: 33287226
pii: cancers12123618
doi: 10.3390/cancers12123618
pmc: PMC7761690
pii:
doi:
Types de publication
Journal Article
Langues
eng
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