Iron: An Essential Element of Cancer Metabolism.
cancer metabolism
iron
iron-sulfur cluster
mitochondria
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
03 12 2020
03 12 2020
Historique:
received:
06
11
2020
revised:
24
11
2020
accepted:
30
11
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
25
6
2021
Statut:
epublish
Résumé
Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in a hostile environment characterized by nutrient deprivation, poor vascularization and immune infiltration. While metabolic reprogramming has been recognized as a hallmark of cancer, the role of micronutrients in shaping these adaptations remains scarcely investigated. In particular, the broad electron-transferring abilities of iron make it a versatile cofactor that is involved in a myriad of biochemical reactions vital to cellular homeostasis, including cell respiration and DNA replication. In cancer patients, systemic iron metabolism is commonly altered. Moreover, cancer cells deploy diverse mechanisms to increase iron bioavailability to fuel tumor growth. Although iron itself can readily participate in redox reactions enabling vital processes, its reactivity also gives rise to reactive oxygen species (ROS). Hence, cancer cells further rely on antioxidant mechanisms to withstand such stress. The present review provides an overview of the common alterations of iron metabolism occurring in cancer and the mechanisms through which iron promotes tumor growth.
Identifiants
pubmed: 33287315
pii: cells9122591
doi: 10.3390/cells9122591
pmc: PMC7761773
pii:
doi:
Substances chimiques
Antioxidants
0
Reactive Oxygen Species
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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