Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study.
Functional connectivity (FC)
Functional magnetic resonance imaging (fMRI)
Median raphe nuclei (MRN)
Migraine
Regional homogeneity (Reho)
Voxel-based Morphometry (VBM)
Journal
The journal of headache and pain
ISSN: 1129-2377
Titre abrégé: J Headache Pain
Pays: England
ID NLM: 100940562
Informations de publication
Date de publication:
07 Dec 2020
07 Dec 2020
Historique:
received:
25
09
2020
accepted:
18
11
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
22
12
2020
Statut:
epublish
Résumé
To explore the possible concurrent brain functional and structural alterations in patients with migraine without aura (MwoA) patients compared to healthy subjects (HS). Seventy-two MwoA patients and forty-six HS were recruited. 3D-T1 and resting state fMRI data were collected during the interictal period for MwoA and HS. Voxel-based morphometry (VBM) for structure analysis and regional homogeneity (Reho) for fMRI analysis were applied. The VBM and Reho maps were overlapped to determine a possible brain region with concurrent functional and structural alteration in MwoA patients. Further analysis of resting state functional connectivity (FC) alteration was applied with this brain region as the seed. Compared with HS, MwoA patients showed decreased volume in the bilateral superior and inferior colliculus, periaqueductal gray matter (PAG), locus ceruleus, median raphe nuclei (MRN) and dorsal pons medulla junction. MwoA patients showed decreased Reho values in the middle occipital gyrus and inferior occipital gyrus, and increased Reho values in the MRN. Only a region in the MRN showed both structural and functional alteration in MwoA patients. Pearson correlation analysis showed that there was no association between volume or Reho values of the MRN and headache frequency, headache intensity, disease duration, self-rating anxiety scale or self-rating depression scale in MwoA patients. Resting state functional connectivity (FC) with the MRN as the seed showed that MwoA patients had increased FC between the MRN and PAG. MRN are involved in the pathophysiology of migraine during the interictal period. This study may help to better understand the migraine symptoms. NCT01152632 . Registered 27 June 2010.
Identifiants
pubmed: 33287704
doi: 10.1186/s10194-020-01203-5
pii: 10.1186/s10194-020-01203-5
pmc: PMC7720576
doi:
Banques de données
ClinicalTrials.gov
['NCT01152632']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
141Subventions
Organisme : National Natural Science Foundation of China
ID : No.81973958
Organisme : National Natural Science Foundation of China
ID : No.81590951
Organisme : National Natural Science Foundation of China
ID : No.81774400
Organisme : China Postdoctoral Science Foundation
ID : No.2017M610593
Organisme : China Postdoctoral Science Foundation
ID : No.2018T110954
Organisme : China Postdoctoral Science Foundation
ID : No.20190037
Organisme : Major Program of Sichuan Provincial Education Department
ID : No.17ZA0157
Références
Curr Opin Neurol. 2018 Aug;31(4):379-385
pubmed: 29952833
Brain Res. 1979 Feb 16;162(1):45-54
pubmed: 761086
Cephalalgia. 2007 Mar;27(3):193-210
pubmed: 17381554
Neuroimage. 2001 Jul;14(1 Pt 1):21-36
pubmed: 11525331
Neurol Sci. 2009 May;30 Suppl 1:S125-7
pubmed: 19415442
Neuroscientist. 2016 Oct;22(5):486-505
pubmed: 26170004
Nat Neurosci. 2015 May;18(5):728-35
pubmed: 25867120
Cephalalgia. 2016 Jul;36(8):800-6
pubmed: 26566936
Cephalalgia. 2000 Nov;20(9):765-86
pubmed: 11167908
Cephalalgia. 2018 Jan;38(1):1-211
pubmed: 29368949
J Headache Pain. 2017 Dec 8;18(1):115
pubmed: 29322264
PLoS One. 2013 Oct 16;8(10):e77933
pubmed: 24147100
Cephalalgia. 1992 Aug;12(4):221-8; discussion 186
pubmed: 1525797
J Neurosci. 2009 Aug 5;29(31):9661-4
pubmed: 19657018
Sci Rep. 2016 Feb 03;6:20298
pubmed: 26839078
Neuroimage. 2004 May;22(1):394-400
pubmed: 15110032
NMR Biomed. 2013 Jan;26(1):58-64
pubmed: 22674568
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
J Comp Neurol. 1986 Aug 22;250(4):498-509
pubmed: 3760251
Cephalalgia. 2015 Jan;35(1):3-9
pubmed: 24812034
Neurology. 2002 Apr 9;58(7):1062-5
pubmed: 11940693
Trends Neurosci. 2002 Jun;25(6):319-25
pubmed: 12086751
Neuropsychopharmacology. 2006 Apr;31(4):814-24
pubmed: 16192985
eNeuro. 2014 Dec 30;1(1):e20.14
pubmed: 25893216
Headache. 1972 Jul;12(2):69-72
pubmed: 4262476
Nat Rev Neurosci. 2011 Sep 20;12(10):570-84
pubmed: 21931334
Cephalalgia. 2012 Jun;32(8):607-20
pubmed: 22623760
Front Neurol. 2019 May 07;10:442
pubmed: 31133962
Prog Neurobiol. 1995 Aug;46(6):575-605
pubmed: 8545545
Cephalalgia. 2008 Jan;28(1):1-4
pubmed: 17986275
J Anat. 2009 May 28;:
pubmed: 19486203
Brain Struct Funct. 2013 Jul;218(4):903-12
pubmed: 22760159
Nat Rev Neurol. 2017 Dec;13(12):725-741
pubmed: 29146952
NMR Biomed. 2012 May;25(5):806-12
pubmed: 22020869
Eur J Neurol. 2003 Jan;10(1):53-7
pubmed: 12534993
J Headache Pain. 2019 May 15;20(1):53
pubmed: 31092190
Neuroimage Clin. 2017 Jan 19;14:130-140
pubmed: 28180071
Cephalalgia. 2009 Jun;29(6):662-9
pubmed: 19210514
Epilepsia. 2013 Nov;54(11):1855-65
pubmed: 24032627
J Psychopharmacol. 2013 Dec;27(12):1107-15
pubmed: 23999409
J Med Syst. 2019 Jul 27;43(9):298
pubmed: 31352647
BMC Psychiatry. 2017 Sep 8;17(1):329
pubmed: 28886698
Ann Neurosci. 2012 Apr;19(2):88-94
pubmed: 25205974
J Cereb Blood Flow Metab. 2019 Apr;39(4):730-739
pubmed: 28737061
J Headache Pain. 2005 Dec;6(6):429-40
pubmed: 16388337
PLoS One. 2012;7(12):e51250
pubmed: 23227257
Braz J Med Biol Res. 2003 May;36(5):557-66
pubmed: 12715074
J Headache Pain. 2016 Dec;17(1):98
pubmed: 27771875
J Clin Neurol. 2012 Jun;8(2):89-99
pubmed: 22787491
J Neuropathol Exp Neurol. 2012 Jun;71(6):531-46
pubmed: 22592840
Cephalalgia. 2004;24 Suppl 1:9-160
pubmed: 14979299
Lancet Neurol. 2015 Jan;14(1):81-91
pubmed: 25496899
Curr Opin Support Palliat Care. 2014 Jun;8(2):137-42
pubmed: 24670810
J Headache Pain. 2013 Jan 10;14:1
pubmed: 23566305
Neurology. 2000 Sep 12;55(5):629-35
pubmed: 10980724
Headache. 2008 Jan;48(1):109-17
pubmed: 18184293