Citalopram intoxication in four week old infant.
Citalopram
Finnegan scores
Infant
Intoxication
SSRI
Journal
BMC pediatrics
ISSN: 1471-2431
Titre abrégé: BMC Pediatr
Pays: England
ID NLM: 100967804
Informations de publication
Date de publication:
07 12 2020
07 12 2020
Historique:
received:
16
12
2019
accepted:
19
11
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
15
5
2021
Statut:
epublish
Résumé
In contrast to intoxications in toddlers which can be due to accidental ingestions, many intoxications in infants are due to medication errors. To our knowledge, this is the first case report of a citalopram intoxication in an infant, and may offer new insight on possible screening methods for intoxication as well as pharmacokinetics of citalopram in small infants. This case report describes an unintentional citalopram intoxication in a 4 week old infant due to a vitamin D drops 'look alike' error. The infant showed extreme jitteriness and opisthotonus at presentation, as well as prolonged signs of gastro-oesophageal reflux. No cardiac rhythm disturbances or convulsions were seen. The clinical course combined with Finnegan scores was correlated to and supported by pharmacokinetic and pharmacokinetic data of citalopram in the patient. Using Finnegan scores in general pediatric practice could help objectify follow-up of acute intoxications in young infants with neurological symptoms.
Sections du résumé
BACKGROUND
In contrast to intoxications in toddlers which can be due to accidental ingestions, many intoxications in infants are due to medication errors. To our knowledge, this is the first case report of a citalopram intoxication in an infant, and may offer new insight on possible screening methods for intoxication as well as pharmacokinetics of citalopram in small infants.
CASE PRESENTATION
This case report describes an unintentional citalopram intoxication in a 4 week old infant due to a vitamin D drops 'look alike' error. The infant showed extreme jitteriness and opisthotonus at presentation, as well as prolonged signs of gastro-oesophageal reflux. No cardiac rhythm disturbances or convulsions were seen. The clinical course combined with Finnegan scores was correlated to and supported by pharmacokinetic and pharmacokinetic data of citalopram in the patient.
CONCLUSIONS
Using Finnegan scores in general pediatric practice could help objectify follow-up of acute intoxications in young infants with neurological symptoms.
Identifiants
pubmed: 33287753
doi: 10.1186/s12887-020-02439-5
pii: 10.1186/s12887-020-02439-5
pmc: PMC7722423
doi:
Substances chimiques
Citalopram
0DHU5B8D6V
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
552Références
Am J Obstet Gynecol. 2011 Jul;205(1):51.e1-8
pubmed: 21514558
QJM. 2003 Sep;96(9):635-42
pubmed: 12925718
Pharmacotherapy. 2017 Jul;37(7):814-823
pubmed: 28519244
Addiction. 2010 Mar;105(3):524-8
pubmed: 20402996
Br J Clin Pharmacol. 2008 Apr;65(4):600-6
pubmed: 17953715
Evid Rep Technol Assess (Summ). 2005 Feb;(119):1-8
pubmed: 15760246
J Psychiatry Neurosci. 2000 May;25(3):241-54
pubmed: 10863884
Semin Fetal Neonatal Med. 2005 Apr;10(2):123-38
pubmed: 15701578
Arch Pediatr Adolesc Med. 2006 Feb;160(2):173-6
pubmed: 16461873
Psychiatry Investig. 2018 Mar;15(3):313-319
pubmed: 29475241
Ther Drug Monit. 2008 Jun;30(3):365-71
pubmed: 18520609
Pharmacogenet Genomics. 2011 Nov;21(11):769-72
pubmed: 21546862
Clin Toxicol (Phila). 2012 Jun;50(5):418-23
pubmed: 22506805
Clin Toxicol (Phila). 2006;44(2):165-8
pubmed: 16615673
Pediatr Nephrol. 2012 Jan;27(1):17-32
pubmed: 21258818