Alternative splicing in endothelial cells: novel therapeutic opportunities in cancer angiogenesis.
Alternative splicing; RNA binding proteins
Angiogenesis
Anti-angiogenic therapy
Endothelial cells
Vascular biology
Journal
Journal of experimental & clinical cancer research : CR
ISSN: 1756-9966
Titre abrégé: J Exp Clin Cancer Res
Pays: England
ID NLM: 8308647
Informations de publication
Date de publication:
07 Dec 2020
07 Dec 2020
Historique:
received:
18
08
2020
accepted:
26
10
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
19
8
2021
Statut:
epublish
Résumé
Alternative splicing (AS) is a pervasive molecular process generating multiple protein isoforms, from a single gene. It plays fundamental roles during development, differentiation and maintenance of tissue homeostasis, while aberrant AS is considered a hallmark of multiple diseases, including cancer. Cancer-restricted AS isoforms represent either predictive biomarkers for diagnosis/prognosis or targets for anti-cancer therapies. Here, we discuss the contribution of AS regulation in cancer angiogenesis, a complex process supporting disease development and progression. We consider AS programs acting in a specific and non-redundant manner to influence morphological and functional changes involved in cancer angiogenesis. In particular, we describe relevant AS variants or splicing regulators controlling either secreted or membrane-bound angiogenic factors, which may represent attractive targets for therapeutic interventions in human cancer.
Identifiants
pubmed: 33287867
doi: 10.1186/s13046-020-01753-1
pii: 10.1186/s13046-020-01753-1
pmc: PMC7720527
doi:
Substances chimiques
Carrier Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
275Subventions
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 2018 Id.21966
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : IG 2016 Id.19032
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