Flavonoids in Bone Erosive Diseases: Perspectives in Osteoporosis Treatment.
bone erosive diseases
flavonoids
osteoblast
osteoclast
osteoporosis
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
05
08
2020
revised:
26
10
2020
accepted:
10
11
2020
pubmed:
9
12
2020
medline:
3
11
2021
entrez:
8
12
2020
Statut:
ppublish
Résumé
Imbalance of bone homeostasis, with excessive bone resorption compared with bone formation, leads to the development of progressive osteopenia leading to lower bone resistance to load, with consequent pain and functional limitations. Phytochemicals with therapeutic and preventive effects against bone resorption have recently received increasing attention since they are potentially more suitable for long-term use than traditional therapeutic chemical compounds. In this systematic review of the literature of the past 5 years, comprehensive information is provided on flavonoids with potential antiresorption and pro-osteogenic effects. It aims to highlight the molecular mechanisms of these molecules, often epigenetic, and their possible pharmacological use, which is of great importance for the prevention and treatment of osteoporosis (OP).
Identifiants
pubmed: 33288387
pii: S1043-2760(20)30225-3
doi: 10.1016/j.tem.2020.11.007
pii:
doi:
Substances chimiques
Flavonoids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
76-94Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.