Rediscussing the Role of Traditional Risk Factors in Young Adults With Oral Squamous Cell Carcinoma.
OSCC
Oral squamous cell carcinoma
alcohol consumption
case-control study
risk factors
smoking
survival analysis
young adults
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
11
10
2020
revised:
25
10
2020
accepted:
27
10
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
18
12
2020
Statut:
ppublish
Résumé
The current literature conjectures that oral squamous cell carcinoma (OSCC) in younger patients is an entirely separate entity with a different risk profile. We aimed to uncover the potential risk factors of OSCC and evaluated the long-term outcome in such patients. This hospital-based case-control study included 40 patients with OSCC and 40 controls under the age of 46 years. Survival was analyzed via Kaplan-Meier estimates, including a follow-up of up to 24.3 years. The patients with OSCC were prone to smoking and drinking heavily and even suffered secondary organ damage to the lungs and the liver at this young age. Early diagnosed as well as surgically treated patients had superior 5-year recurrence-free and overall survival. Young patients with OSCC were found to have a traditional risk profile. Secondary organ damage to the liver and the lungs might be considered as a risk indicator. The meticulous screening of every age group with this risk profile is key to early diagnosis and acceptable treatment results.
Sections du résumé
BACKGROUND/AIM
OBJECTIVE
The current literature conjectures that oral squamous cell carcinoma (OSCC) in younger patients is an entirely separate entity with a different risk profile. We aimed to uncover the potential risk factors of OSCC and evaluated the long-term outcome in such patients.
PATIENTS AND METHODS
METHODS
This hospital-based case-control study included 40 patients with OSCC and 40 controls under the age of 46 years. Survival was analyzed via Kaplan-Meier estimates, including a follow-up of up to 24.3 years.
RESULTS
RESULTS
The patients with OSCC were prone to smoking and drinking heavily and even suffered secondary organ damage to the lungs and the liver at this young age. Early diagnosed as well as surgically treated patients had superior 5-year recurrence-free and overall survival.
CONCLUSION
CONCLUSIONS
Young patients with OSCC were found to have a traditional risk profile. Secondary organ damage to the liver and the lungs might be considered as a risk indicator. The meticulous screening of every age group with this risk profile is key to early diagnosis and acceptable treatment results.
Identifiants
pubmed: 33288593
pii: 40/12/6987
doi: 10.21873/anticanres.14723
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6987-6995Informations de copyright
Copyright © 2020 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.