The V2 loop of HIV gp120 delivers costimulatory signals to CD4
Anti-HIV Agents
/ immunology
Antibodies, Monoclonal
/ immunology
Antibodies, Neutralizing
/ immunology
CD4-Positive T-Lymphocytes
/ drug effects
Cell Proliferation
Epitopes
/ immunology
HIV Envelope Protein gp120
/ chemistry
HIV Infections
/ metabolism
Host-Pathogen Interactions
/ physiology
Humans
Integrins
/ metabolism
Lymphocyte Activation
Protein Domains
Signal Transduction
Simian Immunodeficiency Virus
/ immunology
Tretinoin
/ pharmacology
HIV gp120
HIV reservoir
HIV transmission
HIV vaccine
integrin alpha4beta7
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
22 12 2020
22 12 2020
Historique:
pubmed:
9
12
2020
medline:
20
2
2021
entrez:
8
12
2020
Statut:
ppublish
Résumé
Acute HIV infection is characterized by rapid viral seeding of immunologic inductive sites in the gut followed by the severe depletion of gut CD4
Identifiants
pubmed: 33288704
pii: 2011501117
doi: 10.1073/pnas.2011501117
pmc: PMC7768698
doi:
Substances chimiques
Anti-HIV Agents
0
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Epitopes
0
HIV Envelope Protein gp120
0
Integrins
0
integrin alpha4beta7
0
Tretinoin
5688UTC01R
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
32566-32573Déclaration de conflit d'intérêts
The authors declare no competing interest.
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