Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy.

Animals Antibody Specificity CD4 Antigens / metabolism Dendritic Cells / physiology Forkhead Transcription Factors / metabolism Hypersensitivity / therapy Immunity, Cellular Immunization Immunoglobulins / metabolism Immunotherapy / methods Lymph Nodes / cytology Mice Ovalbumin / immunology T-Lymphocytes, Regulatory / physiology

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
07 12 2020
Historique:
received: 25 02 2020
accepted: 04 11 2020
entrez: 8 12 2020
pubmed: 9 12 2020
medline: 30 6 2021
Statut: epublish

Résumé

While sublingual immunotherapy (SLIT) is known as an allergen-specific treatment for type-1 allergies, how it controls allergic pathogenesis remains unclear. Here, we show the prerequisite role of conventional dendritic cells in submandibular lymph nodes (ManLNs) in the effectiveness of SLIT for the treatment of allergic disorders in mice. Deficiency of conventional dendritic cells or CD4

Identifiants

DOI: 10.1038/s42003-020-01466-3 PMID: 33288832 PMC: PMC7721894
pubmed: 33288832
doi: 10.1038/s42003-020-01466-3
pii: 10.1038/s42003-020-01466-3
pmc: PMC7721894
doi:

Substances chimiques

CD4 Antigens 0
Forkhead Transcription Factors 0
Foxp3 protein, mouse 0
Immunoglobulins 0
Ovalbumin 9006-59-1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

742

Références

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Auteurs

Noriaki Miyanaga (N)

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

Hideaki Takagi (H)

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan.

Tomofumi Uto (T)

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan.

Tomohiro Fukaya (T)

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan.

Junta Nasu (J)

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

Takehito Fukui (T)

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

Yotaro Nishikawa (Y)

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.
Department of Dermatology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

Tim Sparwasser (T)

Department of Medical Microbiology and Hygiene, University Medical Center, Johannes Gutenberg University, 55131, Mainz, Germany.

Narantsog Choijookhuu (N)

Division of Histochemistry and Cell Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.

Yoshitaka Hishikawa (Y)

Division of Histochemistry and Cell Biology, Department of Anatomy, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Japan.

Takeshi Nakamura (T)

Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

Tetsuya Tono (T)

Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan.

Katsuaki Sato (K)

Division of Immunology, Department of Infectious Diseases, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki, 889-1692, Japan. katsuaki_sato@med.miyazaki-u.ac.jp.
Japan Agency for Medical Research and Development (AMED), 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan. katsuaki_sato@med.miyazaki-u.ac.jp.
ORCID: 0000-0002-1844-6620

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Essential role of submandibular lymph node...
questionsmedicales.fr › Phénomènes du système immunitaire › Spécificité des anticorps › Essential role of submandibular lymph node...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigènes CD4 › Essential role of submandibular lymph node...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Essential role of submandibular lymph node...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif hélice ailée › Facteurs de transcription Forkhead › Essential role of submandibular lymph node...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Essential role of submandibular lymph node...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › Essential role of submandibular lymph node...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Essential role of submandibular lymph node...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Essential role of submandibular lymph node...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Essential role of submandibular lymph node...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Essential role of submandibular lymph node...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Essential role of submandibular lymph node...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Ovalbumine › Essential role of submandibular lymph node...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Essential role of submandibular lymph node...