GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors.
Animals
Astrocytes
/ physiology
Cognition
/ drug effects
Decision Making
GABAergic Neurons
/ physiology
Gamma Rhythm
/ physiology
Goals
Interneurons
/ physiology
Memory, Short-Term
/ physiology
Mice
Mice, Inbred C57BL
Mice, Knockout
Optogenetics
Prefrontal Cortex
/ physiology
Psychomotor Performance
/ physiology
Receptors, GABA-B
/ genetics
Rod Opsins
/ pharmacology
Signal Transduction
/ physiology
gamma-Aminobutyric Acid
/ physiology
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
21
12
2019
accepted:
02
11
2020
pubmed:
9
12
2020
medline:
9
3
2021
entrez:
8
12
2020
Statut:
ppublish
Résumé
GABA interneurons play a critical role in higher brain functions. Astrocytic glial cells interact with synapses throughout the whole brain and are recognized as regulatory elements of excitatory synaptic transmission. However, it is largely unknown how GABAergic interneurons and astrocytes interact and contribute to stable performance of complex behaviors. Here, we found that genetic ablation of GABA
Identifiants
pubmed: 33288910
doi: 10.1038/s41593-020-00752-x
pii: 10.1038/s41593-020-00752-x
doi:
Substances chimiques
Receptors, GABA-B
0
Rod Opsins
0
melanopsin
0
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
82-92Références
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