Antigenic variation of SARS-CoV-2 in response to immune pressure.
B cell epitope
COVID‐19
SARS‐CoV‐2
T cell epitope
human coronavirus
sarbecovirus
Journal
Molecular ecology
ISSN: 1365-294X
Titre abrégé: Mol Ecol
Pays: England
ID NLM: 9214478
Informations de publication
Date de publication:
02 Dec 2020
02 Dec 2020
Historique:
received:
03
09
2020
revised:
30
10
2020
accepted:
06
11
2020
entrez:
8
12
2020
pubmed:
9
12
2020
medline:
9
12
2020
Statut:
aheadofprint
Résumé
Analysis of the bat viruses most closely related to SARS-CoV-2 indicated that the virus probably required limited adaptation to spread in humans. Nonetheless, since its introduction in human populations, SARS-CoV-2 must have been subject to the selective pressure imposed by the human immune system. We exploited the availability of a large number of high-quality SARS-CoV-2 genomes, as well as of validated epitope predictions, to show that B cell epitopes in the spike glycoprotein (S) and in the nucleocapsid protein (N) have higher diversity than nonepitope positions. Similar results were obtained for other human coronaviruses and for sarbecoviruses sampled in bats. Conversely, in the SARS-CoV-2 population, epitopes for CD4
Identifiants
pubmed: 33289207
doi: 10.1111/mec.15730
pmc: PMC7753431
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Health
Informations de copyright
© 2020 The Authors. Molecular Ecology published by John Wiley & Sons Ltd.
Références
BMC Genomics. 2012 Jun 20;13:261
pubmed: 22716473
J Immunol. 2020 Aug 1;205(3):555-564
pubmed: 32513850
PLoS Biol. 2019 Sep 9;17(9):e3000436
pubmed: 31498797
J Med Virol. 2020 May;92(5):512-517
pubmed: 32073157
Nat Genet. 2010 Jun;42(6):498-503
pubmed: 20495566
Immunity. 2014 Dec 18;41(6):909-18
pubmed: 25526306
Clin Microbiol Infect. 2020 Jun;26(6):729-734
pubmed: 32234451
Clin Infect Dis. 2020 Nov 19;71(16):2027-2034
pubmed: 32221519
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Adv Physiol Educ. 2010 Sep;34(3):128-33
pubmed: 20826766
Nature. 2020 Mar;579(7798):270-273
pubmed: 32015507
Immunol Res. 2014 Aug;59(1-3):118-28
pubmed: 24845462
J Virol. 2008 Jun;82(11):5594-605
pubmed: 18385228
Immunol Lett. 2020 Oct;226:38-45
pubmed: 32659267
Infect Genet Evol. 2020 Sep;83:104351
pubmed: 32387564
Nature. 2020 Jul;583(7815):286-289
pubmed: 32380510
Nature. 2021 Apr;592(7852):116-121
pubmed: 33106671
Mol Ecol. 2020 Dec 2;:
pubmed: 33289207
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E147-55
pubmed: 25548174
Proc Soc Exp Biol Med. 1972 Mar;139(3):722-7
pubmed: 5063367
J Infect Dis. 2010 Mar 15;201(6):946-55
pubmed: 20144042
J Virol. 2020 Jun 1;94(12):
pubmed: 32238584
Cell Host Microbe. 2015 Nov 11;18(5):538-48
pubmed: 26607161
Mol Biol Evol. 2013 Apr;30(4):772-80
pubmed: 23329690
J Immunol. 2016 Jun 1;196(11):4468-76
pubmed: 27183594
Nat Med. 2020 Aug;26(8):1200-1204
pubmed: 32555424
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Ecol Evol. 2019 Jun 14;9(13):7861-7874
pubmed: 31346446
Nat Med. 2020 Apr;26(4):450-452
pubmed: 32284615
Curr Protoc Immunol. 2016 Aug 01;114:18.19.1-18.19.24
pubmed: 27479659
RNA Biol. 2011 Mar-Apr;8(2):270-9
pubmed: 21593585
Front Mol Biosci. 2020 Jul 03;7:157
pubmed: 32719810
Infect Genet Evol. 2020 Oct;84:104384
pubmed: 32473976
Cell. 2020 Aug 20;182(4):812-827.e19
pubmed: 32697968
PLoS Comput Biol. 2012;8(12):e1002829
pubmed: 23300419
PLoS Biol. 2013;11(4):e1001523
pubmed: 23565057
J Med Virol. 2020 May;92(5):501-511
pubmed: 32027035
Immunity. 2020 Jun 16;52(6):910-941
pubmed: 32505227
J Virol. 2007 Nov;81(22):12382-93
pubmed: 17804494
Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4812-E4821
pubmed: 28559317
Int J Biol Sci. 2020 Mar 15;16(10):1686-1697
pubmed: 32226286
PLoS One. 2020 Sep 9;15(9):e0238089
pubmed: 32903266
mBio. 2020 Oct 16;11(5):
pubmed: 33067385
Nature. 2020 Jul;583(7815):282-285
pubmed: 32218527
Nat Commun. 2015 Aug 06;6:7952
pubmed: 26245473
Nucleic Acids Res. 2017 Jul 3;45(W1):W24-W29
pubmed: 28472356
Nat Commun. 2020 Jul 14;11(1):3581
pubmed: 32665645
PLoS Pathog. 2020 May 14;16(5):e1008421
pubmed: 32407364
PLoS One. 2008 Jun 11;3(6):e2402
pubmed: 18545702
J Virol. 2019 Jan 4;93(2):
pubmed: 30404801
Nat Rev Immunol. 2020 May;20(5):269-270
pubmed: 32273594
J Virol. 2007 Nov;81(22):12179-88
pubmed: 17728222
Cell Host Microbe. 2020 Apr 8;27(4):671-680.e2
pubmed: 32183941
Nat Microbiol. 2020 Nov;5(11):1408-1417
pubmed: 32724171
Nat Rev Immunol. 2020 Jun;20(6):339-341
pubmed: 32317716
Nat Microbiol. 2020 Apr;5(4):536-544
pubmed: 32123347
Nat Rev Microbiol. 2019 Mar;17(3):181-192
pubmed: 30531947
Cell. 2020 Oct 1;183(1):169-184.e13
pubmed: 32931734
Cell Host Microbe. 2021 Jan 13;29(1):23-31.e4
pubmed: 33306985
Nat Microbiol. 2020 Apr;5(4):529-530
pubmed: 32071422
J Infect Dis. 2005 Dec 1;192(11):1898-907
pubmed: 16267760
J Immunol. 2017 Nov 1;199(9):3360-3368
pubmed: 28978689
Emerg Infect Dis. 2019 Jun;25(6):1161-1168
pubmed: 30900977
Emerg Infect Dis. 2020 Jul;26(7):1478-1488
pubmed: 32267220
Glob Chall. 2017 Jan 10;1(1):33-46
pubmed: 31565258
PLoS Genet. 2008 Dec;4(12):e1000304
pubmed: 19081788
Sci Rep. 2016 Feb 15;6:21256
pubmed: 26876644
J Virol. 2006 Apr;80(7):3617-23
pubmed: 16537629
Nat Immunol. 2020 Nov;21(11):1336-1345
pubmed: 32887977
Emerg Infect Dis. 2005 Dec;11(12):1860-5
pubmed: 16485471
Cell. 2015 Aug 13;162(4):738-50
pubmed: 26276630
Immunity. 2020 Jun 16;52(6):971-977.e3
pubmed: 32413330
Nat Commun. 2020 Jun 1;11(1):2806
pubmed: 32483236
Science. 2020 Dec 18;370(6523):1464-1468
pubmed: 33184236
Immunity. 2007 Apr;26(4):397-406
pubmed: 17459809
Trends Microbiol. 2017 Jan;25(1):35-48
pubmed: 27743750
Emerg Infect Dis. 2020 Feb;26(2):191-198
pubmed: 31961300