Dual enzyme responsive mannose-6-phosphate based vesicle for controlled lysosomal delivery.
Alkaline Phosphatase
/ metabolism
Delayed-Action Preparations
/ chemistry
Drug Compounding
Drug Liberation
Esterases
/ metabolism
Fluorescent Dyes
/ chemistry
HEK293 Cells
Humans
Hydrolysis
Kinetics
Lipids
/ chemistry
Liposomes
/ chemistry
Lysosomes
/ chemistry
Mannosephosphates
/ chemistry
Time Factors
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
05 Jan 2021
05 Jan 2021
Historique:
pubmed:
9
12
2020
medline:
4
6
2021
entrez:
8
12
2020
Statut:
ppublish
Résumé
Dual enzyme responsive stable biomimetic vesicles composed of mannose-6-phosphate lipid can encapsulate and deliver dual dye/drug and protein/enzyme exclusively to the lysosome in HEK-293 cells. The release of the cargo from the vesicles can be temporally controlled due to the enzyme responsive morphology change of the M6P lipid assembly.
Substances chimiques
Delayed-Action Preparations
0
Fluorescent Dyes
0
Lipids
0
Liposomes
0
Mannosephosphates
0
mannose-6-phosphate
3672-15-9
Esterases
EC 3.1.-
Alkaline Phosphatase
EC 3.1.3.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM