The Gene Ontology resource: enriching a GOld mine.
Animals
Arabidopsis
/ genetics
Caenorhabditis elegans
/ genetics
Dictyostelium
/ genetics
Drosophila melanogaster
/ genetics
Escherichia coli
/ genetics
Gene Ontology
Humans
Internet
Mice
Molecular Sequence Annotation
/ statistics & numerical data
Rats
Saccharomyces cerevisiae
/ genetics
Schizosaccharomyces
/ genetics
User-Computer Interface
Zebrafish
/ genetics
Journal
Nucleic acids research
ISSN: 1362-4962
Titre abrégé: Nucleic Acids Res
Pays: England
ID NLM: 0411011
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
accepted:
02
12
2020
revised:
22
10
2020
received:
15
09
2020
pubmed:
9
12
2020
medline:
21
1
2021
entrez:
8
12
2020
Statut:
ppublish
Résumé
The Gene Ontology Consortium (GOC) provides the most comprehensive resource currently available for computable knowledge regarding the functions of genes and gene products. Here, we report the advances of the consortium over the past two years. The new GO-CAM annotation framework was notably improved, and we formalized the model with a computational schema to check and validate the rapidly increasing repository of 2838 GO-CAMs. In addition, we describe the impacts of several collaborations to refine GO and report a 10% increase in the number of GO annotations, a 25% increase in annotated gene products, and over 9,400 new scientific articles annotated. As the project matures, we continue our efforts to review older annotations in light of newer findings, and, to maintain consistency with other ontologies. As a result, 20 000 annotations derived from experimental data were reviewed, corresponding to 2.5% of experimental GO annotations. The website (http://geneontology.org) was redesigned for quick access to documentation, downloads and tools. To maintain an accurate resource and support traceability and reproducibility, we have made available a historical archive covering the past 15 years of GO data with a consistent format and file structure for both the ontology and annotations.
Identifiants
pubmed: 33290552
pii: 6027811
doi: 10.1093/nar/gkaa1113
pmc: PMC7779012
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
D325-D334Subventions
Organisme : Wellcome Trust
ID : 212925/Z/18/Z
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : U24 HG002223
Pays : United States
Organisme : National Science Foundation
ID : IOS 1127112
Pays : International
Organisme : NCI NIH HHS
ID : R01 CA152057
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL064541
Pays : United States
Organisme : National Science Foundation
ID : IOS 1340112
Pays : International
Organisme : Medical Research Council
ID : MR/S000453/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104967/Z/14/Z
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : 1R24GM137770-01
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG007822
Pays : United States
Organisme : Wellcome Trust
ID : 108433/Z/15/Z
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : R01 GM080646
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG002659
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG001315
Pays : United States
Organisme : NHGRI NIH HHS
ID : P41 HG002659
Pays : United States
Organisme : NIGMS NIH HHS
ID : U01 GM120953
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM089636
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG002273
Pays : United States
Organisme : National Science Foundation
ID : 1458400
Pays : International
Organisme : NHGRI NIH HHS
ID : U41 HG000739
Pays : United States
Organisme : NHGRI NIH HHS
ID : U41 HG007822
Pays : United States
Organisme : National Science Foundation
ID : 1565146
Pays : International
Organisme : NIGMS NIH HHS
ID : P20 GM103446
Pays : United States
Organisme : NHGRI NIH HHS
ID : P41 HG003751
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG001315
Pays : United States
Organisme : Medical Research Council
ID : MR/N030117/1
Pays : United Kingdom
Organisme : NHGRI NIH HHS
ID : HG 000330
Pays : United States
Investigateurs
Seth Carbon
(S)
Eric Douglass
(E)
Benjamin M Good
(BM)
Deepak R Unni
(DR)
Nomi L Harris
(NL)
Christopher J Mungall
(CJ)
Siddartha Basu
(S)
Rex L Chisholm
(RL)
Robert J Dodson
(RJ)
Eric Hartline
(E)
Petra Fey
(P)
Paul D Thomas
(PD)
Laurent-Philippe Albou
(LP)
Dustin Ebert
(D)
Michael J Kesling
(MJ)
Huaiyu Mi
(H)
Anushya Muruganujan
(A)
Xiaosong Huang
(X)
Tremayne Mushayahama
(T)
Sandra A LaBonte
(SA)
Deborah A Siegele
(DA)
Giulia Antonazzo
(G)
Helen Attrill
(H)
Nick H Brown
(NH)
Phani Garapati
(P)
Steven J Marygold
(SJ)
Vitor Trovisco
(V)
Gil Dos Santos
(G)
Kathleen Falls
(K)
Christopher Tabone
(C)
Pinglei Zhou
(P)
Joshua L Goodman
(JL)
Victor B Strelets
(VB)
Jim Thurmond
(J)
Penelope Garmiri
(P)
Rizwan Ishtiaq
(R)
Milagros Rodríguez-López
(M)
Marcio L Acencio
(ML)
Martin Kuiper
(M)
Astrid Lægreid
(A)
Colin Logie
(C)
Ruth C Lovering
(RC)
Barbara Kramarz
(B)
Shirin C C Saverimuttu
(SCC)
Sandra M Pinheiro
(SM)
Heather Gunn
(H)
Renzhi Su
(R)
Katherine E Thurlow
(KE)
Marcus Chibucos
(M)
Michelle Giglio
(M)
Suvarna Nadendla
(S)
James Munro
(J)
Rebecca Jackson
(R)
Margaret J Duesbury
(MJ)
Noemi Del-Toro
(N)
Birgit H M Meldal
(BHM)
Kalpana Paneerselvam
(K)
Livia Perfetto
(L)
Pablo Porras
(P)
Sandra Orchard
(S)
Anjali Shrivastava
(A)
Hsin-Yu Chang
(HY)
Robert Daniel Finn
(RD)
Alexander Lawson Mitchell
(AL)
Neil David Rawlings
(ND)
Lorna Richardson
(L)
Amaia Sangrador-Vegas
(A)
Judith A Blake
(JA)
Karen R Christie
(KR)
Mary E Dolan
(ME)
Harold J Drabkin
(HJ)
David P Hill
(DP)
Li Ni
(L)
Dmitry M Sitnikov
(DM)
Midori A Harris
(MA)
Stephen G Oliver
(SG)
Kim Rutherford
(K)
Valerie Wood
(V)
Jaqueline Hayles
(J)
Jürg Bähler
(J)
Elizabeth R Bolton
(ER)
Jeffery L De Pons
(JL)
Melinda R Dwinell
(MR)
G Thomas Hayman
(GT)
Mary L Kaldunski
(ML)
Anne E Kwitek
(AE)
Stanley J F Laulederkind
(SJF)
Cody Plasterer
(C)
Marek A Tutaj
(MA)
Mahima Vedi
(M)
Shur-Jen Wang
(SJ)
Peter D'Eustachio
(P)
Lisa Matthews
(L)
James P Balhoff
(JP)
Suzi A Aleksander
(SA)
Michael J Alexander
(MJ)
J Michael Cherry
(JM)
Stacia R Engel
(SR)
Felix Gondwe
(F)
Kalpana Karra
(K)
Stuart R Miyasato
(SR)
Robert S Nash
(RS)
Matt Simison
(M)
Marek S Skrzypek
(MS)
Shuai Weng
(S)
Edith D Wong
(ED)
Marc Feuermann
(M)
Pascale Gaudet
(P)
Anne Morgat
(A)
Erica Bakker
(E)
Tanya Z Berardini
(TZ)
Leonore Reiser
(L)
Shabari Subramaniam
(S)
Eva Huala
(E)
Cecilia N Arighi
(CN)
Andrea Auchincloss
(A)
Kristian Axelsen
(K)
Ghislaine Argoud-Puy
(G)
Alex Bateman
(A)
Marie-Claude Blatter
(MC)
Emmanuel Boutet
(E)
Emily Bowler
(E)
Lionel Breuza
(L)
Alan Bridge
(A)
Ramona Britto
(R)
Hema Bye-A-Jee
(H)
Cristina Casals Casas
(CC)
Elisabeth Coudert
(E)
Paul Denny
(P)
Anne Estreicher
(A)
Maria Livia Famiglietti
(ML)
George Georghiou
(G)
Arnaud Gos
(A)
Nadine Gruaz-Gumowski
(N)
Emma Hatton-Ellis
(E)
Chantal Hulo
(C)
Alexandr Ignatchenko
(A)
Florence Jungo
(F)
Kati Laiho
(K)
Philippe Le Mercier
(P)
Damien Lieberherr
(D)
Antonia Lock
(A)
Yvonne Lussi
(Y)
Alistair MacDougall
(A)
Michele Magrane
(M)
Maria J Martin
(MJ)
Patrick Masson
(P)
Darren A Natale
(DA)
Nevila Hyka-Nouspikel
(N)
Sandra Orchard
(S)
Ivo Pedruzzi
(I)
Lucille Pourcel
(L)
Sylvain Poux
(S)
Sangya Pundir
(S)
Catherine Rivoire
(C)
Elena Speretta
(E)
Shyamala Sundaram
(S)
Nidhi Tyagi
(N)
Kate Warner
(K)
Rossana Zaru
(R)
Cathy H Wu
(CH)
Alexander D Diehl
(AD)
Juancarlos N Chan
(JN)
Christian Grove
(C)
Raymond Y N Lee
(RYN)
Hans-Michael Muller
(HM)
Daniela Raciti
(D)
Kimberly Van Auken
(K)
Paul W Sternberg
(PW)
Matthew Berriman
(M)
Michael Paulini
(M)
Kevin Howe
(K)
Sibyl Gao
(S)
Adam Wright
(A)
Lincoln Stein
(L)
Douglas G Howe
(DG)
Sabrina Toro
(S)
Monte Westerfield
(M)
Pankaj Jaiswal
(P)
Laurel Cooper
(L)
Justin Elser
(J)
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.
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