Generation of two human induced pluripotent stem cell lines, UNIBSi012-A and UNIBSi013-A, from two patients with treatment-resistant depression.
Journal
Stem cell research
ISSN: 1876-7753
Titre abrégé: Stem Cell Res
Pays: England
ID NLM: 101316957
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
03
09
2020
revised:
18
11
2020
accepted:
27
11
2020
pubmed:
9
12
2020
medline:
22
6
2021
entrez:
8
12
2020
Statut:
ppublish
Résumé
Novel and complementary experimental models are required for investigating the molecular mechanisms underlying the resistance to the available therapies of patients with major depression (Treatment-Resistant Depression, TRD) that occurs in at least one third of patients and need to be deeply investigated. Here, we have established a patient-specific disease model for TRD by reprogramming peripheral blood mononuclear cells (PBMCs) from two TRD patients into induced pluripotent stem cells (iPSCs), using non-integrating Sendai virus. These lines show the typical morphology of pluripotent cells, express pluripotency markers and displayed in vitro differentiation potential toward cells of the three embryonic germ layers.
Identifiants
pubmed: 33291010
pii: S1873-5061(20)30405-0
doi: 10.1016/j.scr.2020.102104
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
102104Informations de copyright
Copyright © 2020. Published by Elsevier B.V.