Orexin B inhibits viability and differentiation of stromal cells from swine adipose tissue.
Adipose stromal cells
Adipose tissue
OXB
Pig
Journal
Domestic animal endocrinology
ISSN: 1879-0054
Titre abrégé: Domest Anim Endocrinol
Pays: United States
ID NLM: 8505191
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
03
07
2020
revised:
14
10
2020
accepted:
08
11
2020
pubmed:
9
12
2020
medline:
1
4
2022
entrez:
8
12
2020
Statut:
ppublish
Résumé
Adipose tissue is recognized as a fundamental endocrine organ. Nowadays, we are also aware that it contains the highest number of stromal cells (ASCs) per unit of volume. These cells can differentiate between different phenotypes among which the adipocytes. The aim of this work was to verify whether orexin B, crucial mediator of the energy balance, modifies the differentiation of cultured ASCs. We used the pig as a model. Our data demonstrate that swine ASCs express prepro-orexin. Orexin B treatment inhibits ASCs proliferation (P < 0.05) and adipogenic differentiation (P < 0.05). Data collected could be interesting both in animal production field because consumers require lean meat, and in human medicine study about obesity because pig can be considered a valuable animal model for translational studies.
Identifiants
pubmed: 33291037
pii: S0739-7240(20)30161-2
doi: 10.1016/j.domaniend.2020.106594
pii:
doi:
Substances chimiques
Orexins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106594Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.