Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A

Animals Anxiety / etiology Behavior, Animal Cell Membrane / metabolism Darkness Dose-Response Relationship, Drug Guanosine / adverse effects Hippocampus / metabolism Light Rats Receptor, Adenosine A1 / genetics Receptor, Adenosine A2A / genetics
A1R A2AR adenosine behavior caffeine guanosine

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
05 Dec 2020
Historique:
received: 24 10 2020
revised: 30 11 2020
accepted: 03 12 2020
entrez: 9 12 2020
pubmed: 10 12 2020
medline: 5 3 2021
Statut: epublish

Résumé

Acute or chronic administration of guanosine (GUO) induces anxiolytic-like effects, for which the adenosine (ADO) system involvement has been postulated yet without a direct experimental evidence. Thus, we aimed to investigate whether adenosine receptors (ARs) are involved in the GUO-mediated anxiolytic-like effect, evaluated by three anxiety-related paradigms in rats. First, we confirmed that acute treatment with GUO exerts an anxiolytic-like effect. Subsequently, we investigated the effects of pretreatment with ADO or A

Identifiants

DOI: 10.3390/ijms21239281 PMID: 33291390 PMC: PMC7729560
pubmed: 33291390
pii: ijms21239281
doi: 10.3390/ijms21239281
pmc: PMC7729560
pii:
doi:

Substances chimiques

Receptor, Adenosine A1 0
Receptor, Adenosine A2A 0
Guanosine 12133JR80S

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : MINECO/ISCIII
ID : SAF2017-87349-R

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Auteurs

Monica Frinchi (M)

Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy.

Vincenzo Verdi (V)

Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy.
Institut de Psychiatrie et Neurosciences de Paris, INSERM U1266, Université de Paris, F-75014 Paris, France.
ORCID: 0000-0002-7963-5732

Fulvio Plescia (F)

Department of Sciences for Health Promotion and Mother and Child Care "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy.
ORCID: 0000-0002-4786-8435

Francisco Ciruela (F)

Unitat de Farmacologia, Departament Patologia i Terapèutica Experimental, Facultat de Medicina i Ciències de la Salut, IDIBELL, Universitat de Barcelona, 08907 Barcelona, Spain.
Institut de Neurociències, Universitat de Barcelona, 08035 Barcelona, Spain.
ORCID: 0000-0003-0832-3739

Maria Grillo (M)

Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy.

Roberta Garozzo (R)

Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy.

Daniele F Condorelli (DF)

Department of Biomedical and Biotechnological Sciences, Section of Medical Biochemistry, University of Catania, 95123 Catania, Italy.
Laboratory of Complex Systems, Scuola Superiore di Catania, University of Catania, 95123 Catania, Italy.
ORCID: 0000-0002-0311-5386

Patrizia Di Iorio (P)

Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.
Center for Advanced Studies and Technologies (CAST), University of Chieti-Pescara, 66100 Chieti, Italy.

Francesco Caciagli (F)

Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.

Renata Ciccarelli (R)

Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, 66100 Chieti, Italy.
Center for Advanced Studies and Technologies (CAST), University of Chieti-Pescara, 66100 Chieti, Italy.
ORCID: 0000-0003-1412-738X

Natale Belluardo (N)

Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy.

Valentina Di Liberto (V)

Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy.

Giuseppa Mudò (G)

Department of Biomedicine, Neuroscience and Advanced Diagnostic, University of Palermo, 90134 Palermo, Italy.
ORCID: 0000-0002-3275-9981

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Phénomènes physiques › Phénomènes optiques › Obscurité › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Guanosine › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Hippocampe › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement non ionisant › Lumière › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteur A1 à l'adénosine › Guanosine-Mediated Anxiolytic-Like Effect:...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteurs A2 à l'adénosine › Récepteur A2A à l'adénosine › Guanosine-Mediated Anxiolytic-Like Effect:...