Withanolide-Type Steroids from
Withania aristata
anti-leukemia activity
drug-likeness prediction
structure–activity relationship
withasteroids
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
05 Dec 2020
05 Dec 2020
Historique:
received:
06
11
2020
revised:
26
11
2020
accepted:
03
12
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
15
4
2021
Statut:
epublish
Résumé
Leukemia is a blood or bone marrow cancer with increasing incidence in developed regions of the world. Currently, there is an ongoing need for novel and safe anti-leukemic agents, as no fully effective chemotherapy is available to treat this life-threatening disease. Herein, are reported the isolation, structural elucidation, and anti-leukemic evaluation of twenty-nine withanolide-type steroids (
Identifiants
pubmed: 33291428
pii: molecules25235744
doi: 10.3390/molecules25235744
pmc: PMC7731379
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Steroids
0
Withanolides
0
withaferin A
L6DO3QW4K5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Nat Prod. 2002 Jul;65(7):1049-51
pubmed: 12141873
Apoptosis. 2007 Nov;12(11):2115-33
pubmed: 17874299
Cancer Sci. 2016 Sep;107(9):1302-14
pubmed: 27311589
Chem Pharm Bull (Tokyo). 2004 Nov;52(11):1358-61
pubmed: 15520512
Nanomaterials (Basel). 2020 Feb 06;10(2):
pubmed: 32041219
Phytochemistry. 2008 Feb;69(4):1000-4
pubmed: 18061221
Drug Des Devel Ther. 2017 Jun 22;11:1859-1870
pubmed: 28694686
J Nat Prod. 2020 Apr 24;83(4):1309-1313
pubmed: 32233438
Steroids. 2010 Dec;75(12):974-81
pubmed: 20542049
Tumour Biol. 2016 Oct;37(10):14271-14290
pubmed: 27592256
Apoptosis. 2008 Dec;13(12):1494-504
pubmed: 19002588
ACS Chem Biol. 2015 Aug 21;10(8):1916-1924
pubmed: 26006219
Eur J Med Chem. 2017 Nov 10;140:52-64
pubmed: 28923386
Mini Rev Med Chem. 2020;20(12):1101-1117
pubmed: 29189150
J Nat Prod. 2020 Mar 27;83(3):770-803
pubmed: 32162523
Children (Basel). 2020 Feb 02;7(2):
pubmed: 32024232
Nutrients. 2019 May 03;11(5):
pubmed: 31058874
Apoptosis. 2008 Dec;13(12):1450-64
pubmed: 18987975
J Immunol Methods. 1983 Dec 16;65(1-2):55-63
pubmed: 6606682
Int J Mol Sci. 2016 Feb 18;17(2):246
pubmed: 26901192
Cancer Chemother Rep. 1967 Sep;51(5):271-6
pubmed: 6062297
J Med Chem. 2019 May 9;62(9):4571-4585
pubmed: 31008605
F1000Res. 2018 Aug 6;7:
pubmed: 30135719
Eur J Med Chem. 2012 Aug;54:499-511
pubmed: 22705001
Mol Cell Biochem. 2011 Mar;349(1-2):41-55
pubmed: 21125317
Cold Spring Harb Perspect Med. 2020 Jun 1;10(6):
pubmed: 31727680
Expert Opin Drug Discov. 2020 Dec;15(12):1473-1487
pubmed: 32735147
Neoplasma. 1984;31(1):31-6
pubmed: 6700792
Biochem Pharmacol. 2020 Mar;173:113602
pubmed: 31404528
Adv Drug Deliv Rev. 2002 Mar 31;54(3):355-66
pubmed: 11922952
Chem Biol Interact. 2020 Feb 1;317:108963
pubmed: 31978391
Curr Hematol Malig Rep. 2019 Oct;14(5):386-394
pubmed: 31350639
Phytochemistry. 2005 Dec;66(23):2702-7
pubmed: 16293277