Mapping the Relative Biological Effectiveness of Proton, Helium and Carbon Ions with High-Throughput Techniques.
charged particle therapy
high-throughput techniques
lung cancer cells
relative biological effectiveness
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
05 Dec 2020
05 Dec 2020
Historique:
received:
29
10
2020
revised:
26
11
2020
accepted:
04
12
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
10
12
2020
Statut:
epublish
Résumé
Large amounts of high quality biophysical data are needed to improve current biological effects models but such data are lacking and difficult to obtain. The present study aimed to more efficiently measure the spatial distribution of relative biological effectiveness (RBE) of charged particle beams using a novel high-accuracy and high-throughput experimental platform. Clonogenic survival was selected as the biological endpoint for two lung cancer cell lines, H460 and H1437, irradiated with protons, carbon, and helium ions. Ion-specific multi-step microplate holders were fabricated such that each column of a 96-well microplate is spatially situated at a different location along a particle beam path. Dose, dose-averaged linear energy transfer (LET
Identifiants
pubmed: 33291477
pii: cancers12123658
doi: 10.3390/cancers12123658
pmc: PMC7762185
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : Cancer Prevention and Research Institute of Texas
ID : RP150578
Organisme : NCI NIH HHS
ID : CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : CA187484
Pays : United States
Organisme : Cancer Prevention and Research Institute of Texas
ID : RP170067
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