Emerging Roles of PRDM Factors in Stem Cells and Neuronal System: Cofactor Dependent Regulation of PRDM3/16 and FOG1/2 (Novel PRDM Factors).
Animals
Cell Differentiation
Chromatin
/ metabolism
DNA-Binding Proteins
/ metabolism
Gene Expression Regulation
Humans
MDS1 and EVI1 Complex Locus Protein
/ metabolism
Mi-2 Nucleosome Remodeling and Deacetylase Complex
/ metabolism
Mice
Mutation
Neurons
/ metabolism
Neurosciences
Nuclear Proteins
/ metabolism
Positive Regulatory Domain I-Binding Factor 1
/ metabolism
Protein Domains
Risk
Stem Cells
/ cytology
Transcription Factors
/ metabolism
CtBP
FOG
NuRD
PRDM
neurons
stem cells
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 12 2020
04 12 2020
Historique:
received:
13
10
2020
revised:
13
11
2020
accepted:
25
11
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
10
7
2021
Statut:
epublish
Résumé
PRDI-BF1 (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) (PR) homologous domain containing (PRDM) transcription factors are expressed in neuronal and stem cell systems, and they exert multiple functions in a spatiotemporal manner. Therefore, it is believed that PRDM factors cooperate with a number of protein partners to regulate a critical set of genes required for maintenance of stem cell self-renewal and differentiation through genetic and epigenetic mechanisms. In this review, we summarize recent findings about the expression of PRDM factors and function in stem cell and neuronal systems with a focus on cofactor-dependent regulation of PRDM3/16 and FOG1/2. We put special attention on summarizing the effects of the PRDM proteins interaction with chromatin modulators (NuRD complex and CtBPs) on the stem cell characteristic and neuronal differentiation. Although PRDM factors are known to possess intrinsic enzyme activity, our literature analysis suggests that cofactor-dependent regulation of PRDM3/16 and FOG1/2 is also one of the important mechanisms to orchestrate bidirectional target gene regulation. Therefore, determining stem cell and neuronal-specific cofactors will help better understanding of PRDM3/16 and FOG1/2-controlled stem cell maintenance and neuronal differentiation. Finally, we discuss the clinical aspect of these PRDM factors in different diseases including cancer. Overall, this review will help further sharpen our knowledge of the function of the PRDM3/16 and FOG1/2 with hopes to open new research fields related to these factors in stem cell biology and neuroscience.
Identifiants
pubmed: 33291744
pii: cells9122603
doi: 10.3390/cells9122603
pmc: PMC7761934
pii:
doi:
Substances chimiques
Chromatin
0
DNA-Binding Proteins
0
MDS1 and EVI1 Complex Locus Protein
0
MECOM protein, human
0
Nuclear Proteins
0
PRDM16 protein, human
0
Transcription Factors
0
ZFPM1 protein, human
0
ZFPM2 protein, human
0
PRDM1 protein, human
138415-26-6
Positive Regulatory Domain I-Binding Factor 1
EC 2.1.1.-
Mi-2 Nucleosome Remodeling and Deacetylase Complex
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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