Pathogen burden and leukocyte telomere length in the United States.
Biological aging
Geroscience
Immunosenescence
Persistent infections
Telomere length
Journal
Immunity & ageing : I & A
ISSN: 1742-4933
Titre abrégé: Immun Ageing
Pays: England
ID NLM: 101235427
Informations de publication
Date de publication:
19 Nov 2020
19 Nov 2020
Historique:
received:
12
06
2020
accepted:
03
11
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
10
12
2020
Statut:
epublish
Résumé
Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. We estimated cross-sectional associations between seropositivity to five persistent pathogens (Herpes Simplex Virus Type-1 (HSV-1), Herpes Simplex Virus Type-2 (HSV-2), cytomegalovirus (CMV), Helicobacter pylori (H.pylori), and Hepatitis B) as well as total pathogen burden and leukocyte telomere length. Data were derived from the National Health and Nutrition Examination Survey (1999-2000) for individuals 20-49 years of age, N = 1708. We analyzed the influence of each pathogen separately, a pathogen count score and a latent class model of pathogen burden on log telomere length using linear regression models, adjusted for covariates. Individuals in a latent pathogen burden class characterized by high probabilities of infection with HSV-1, CMV, and H. pylori, had significantly decreased log telomere length (- 0.30 [95% CI: - 0.36, - 0.24]) compared to those in a latent class characterized by low probabilities of all five infections. There were limited significant associations using other pathogen measures. These results suggest that infection with specific combinations of pathogens may be one mechanism contributing to accelerated cellular senescence with possible origins early in the life course.
Sections du résumé
BACKGROUND
BACKGROUND
Prior studies in humans have suggested that telomere shortening may be accelerated by infection, but research on multiple pathogens and use of large population-based study samples has been limited. We estimated cross-sectional associations between seropositivity to five persistent pathogens (Herpes Simplex Virus Type-1 (HSV-1), Herpes Simplex Virus Type-2 (HSV-2), cytomegalovirus (CMV), Helicobacter pylori (H.pylori), and Hepatitis B) as well as total pathogen burden and leukocyte telomere length. Data were derived from the National Health and Nutrition Examination Survey (1999-2000) for individuals 20-49 years of age, N = 1708. We analyzed the influence of each pathogen separately, a pathogen count score and a latent class model of pathogen burden on log telomere length using linear regression models, adjusted for covariates.
RESULTS
RESULTS
Individuals in a latent pathogen burden class characterized by high probabilities of infection with HSV-1, CMV, and H. pylori, had significantly decreased log telomere length (- 0.30 [95% CI: - 0.36, - 0.24]) compared to those in a latent class characterized by low probabilities of all five infections. There were limited significant associations using other pathogen measures.
CONCLUSIONS
CONCLUSIONS
These results suggest that infection with specific combinations of pathogens may be one mechanism contributing to accelerated cellular senescence with possible origins early in the life course.
Identifiants
pubmed: 33292353
doi: 10.1186/s12979-020-00206-9
pii: 10.1186/s12979-020-00206-9
pmc: PMC7677839
doi:
Types de publication
Journal Article
Langues
eng
Pagination
36Subventions
Organisme : NIA NIH HHS
ID : P30 AG021342
Pays : United States
Organisme : NIA NIH HHS
ID : K99AG062749-01A1
Pays : United States
Organisme : NIA NIH HHS
ID : AG000029-41
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007168
Pays : United States
Organisme : NIA NIH HHS
ID : R01AG033592
Pays : United States
Organisme : NICHD NIH HHS
ID : R25 HD083146
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD091058
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG000029
Pays : United States
Organisme : NICHD NIH HHS
ID : P2C HD050924
Pays : United States
Références
BMJ. 2014 Jul 08;349:g4227
pubmed: 25006006
Proc Biol Sci. 2016 Aug 17;283(1836):
pubmed: 27488651
Soc Sci Med. 2013 May;85:1-8
pubmed: 23540359
Haematologica. 2017 Aug;102(8):1457-1465
pubmed: 28522577
Cancer Epidemiol Biomarkers Prev. 2011 Jun;20(6):1238-50
pubmed: 21467229
Eur J Hum Genet. 2013 Oct;21(10):1163-8
pubmed: 23321625
J Infect Dis. 2015 Oct 15;212(8):1261-9
pubmed: 25828247
Exp Gerontol. 2013 Apr;48(4):385-90
pubmed: 23403382
JAMA. 2013 Feb 20;309(7):699-705
pubmed: 23423415
J Gerontol A Biol Sci Med Sci. 2011 Mar;66(3):312-9
pubmed: 21310811
Aging Cell. 2018 Feb;17(1):
pubmed: 29143441
J Natl Cancer Inst. 2015 Apr 10;107(6):djv074
pubmed: 25862531
Science. 1996 Nov 29;274(5292):1543-7
pubmed: 8929418
Geroscience. 2017 Jun;39(3):261-271
pubmed: 28624868
Cancer Genet Cytogenet. 2008 Nov;187(1):34-8
pubmed: 18992639
Epidemiol Infect. 2017 Oct;145(14):3076-3084
pubmed: 28879822
Curr Aging Sci. 2014;7(3):161-7
pubmed: 25612739
Viruses. 2017 Oct 05;9(10):
pubmed: 28981470
J Infect Dis. 2008 Nov 1;198(9):1353-7
pubmed: 18816191
J Immunol. 2010 Apr 1;184(7):3417-23
pubmed: 20176738
Sleep. 2019 Jul 8;42(7):
pubmed: 30994174
Front Immunol. 2013 Sep 13;4:271
pubmed: 24062739
Exp Gerontol. 2011 Feb-Mar;46(2-3):135-40
pubmed: 20833238
Nucleic Acids Res. 2002 May 15;30(10):e47
pubmed: 12000852
Mol Psychiatry. 2015 Apr;20(4):520-8
pubmed: 25178165
Epidemiol Infect. 2015 Sep;143(12):2624-34
pubmed: 25518978
Exp Gerontol. 2014 Mar;51:15-27
pubmed: 24365661
Psychoneuroendocrinology. 2019 Apr;102:182-188
pubmed: 30576944
Clin Infect Dis. 2006 Nov 1;43(9):1143-51
pubmed: 17029132
Struct Equ Modeling. 2015 Jan;22(1):1-11
pubmed: 25614730
Vital Health Stat 2. 2013 Sep;(161):1-24
pubmed: 25090154
Psychoneuroendocrinology. 2019 Sep;107:70-81
pubmed: 31112903
Clin Exp Med. 2016 Feb;16(1):65-71
pubmed: 25563818
Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):2029-34
pubmed: 22679311
J Infect Dis. 2017 Sep 1;216(5):565-572
pubmed: 28931225
Science. 2015 Jan 23;347(6220):436-8
pubmed: 25613889
Psychoneuroendocrinology. 2016 May;67:153-62
pubmed: 26897704
Soc Sci Med. 2016 Oct;166:77-85
pubmed: 27543684
Epidemiology. 2015 Jul;26(4):528-35
pubmed: 26039272
Mol Psychiatry. 2015 Apr;20(4):529-35
pubmed: 25070535
Biol Lett. 2019 May 31;15(5):20190190
pubmed: 31113307
Physiol Rev. 2008 Apr;88(2):557-79
pubmed: 18391173
PLoS One. 2008 May 14;3(5):e2143
pubmed: 18478110
Ann Med. 2012 Jun;44 Suppl 1:S138-42
pubmed: 22713142