Analysis of patients' request to switch from a generic drug to the original drug in external prescriptions.
External prescription
Generic drug
Inquiries
Original drug
Journal
Journal of pharmaceutical health care and sciences
ISSN: 2055-0294
Titre abrégé: J Pharm Health Care Sci
Pays: England
ID NLM: 101672177
Informations de publication
Date de publication:
04 Dec 2020
04 Dec 2020
Historique:
received:
24
08
2020
accepted:
26
10
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
10
12
2020
Statut:
epublish
Résumé
Generic drugs are heavily promoted in Japan. The aim of this retrospective single-center study was to clarify whether the frequency and reason that patients request a switch from a generic drug to the original drug differ according to therapeutic category and dosage form. This study was performed at Chiba University Hospital. Prescription inquiries about 121 generic drugs from community pharmacies over a 3-year period (from July 2014 to June 2017) were analyzed. Approximately 30% of the requests were related to the efficacy, safety, and comfort of the generic drug. The most cited motive was "patient's desire with no reason given" at 44.5%. According to multiple logistic regression analysis, therapeutic categories and dosage forms were associated with the requests. The median request frequency differed according to therapeutic category and dosage form. The frequency was highest for "agents affecting the central nervous system" and "tablets and capsules", respectively. Among the therapeutic categories, "agents affecting the central nervous system" had the highest median number of requests related to "decreased effectiveness"; "cardiovascular agents" had the highest median number of requests related to "physician's instruction"; and "agents for the epidermis" had the highest median number of requests related to "uncomfortable to use". Among dosage forms, the odds ratio for patients' original drug request for "liniment and patch" was about 1.5 times that for "tablets and capsules". "Liniment and patch" had the highest median frequency of requests related to "decreased effectiveness", "uncomfortable to use", and "patient's desire with no reason given". The request frequency and reason differed according to therapeutic category and dosage form. Pharmacists should advise each patient properly about the choice and switching of drug brands, taking into account the therapeutic category and dosage form, especially liniments and patches.
Sections du résumé
BACKGROUND
BACKGROUND
Generic drugs are heavily promoted in Japan. The aim of this retrospective single-center study was to clarify whether the frequency and reason that patients request a switch from a generic drug to the original drug differ according to therapeutic category and dosage form.
METHODS
METHODS
This study was performed at Chiba University Hospital. Prescription inquiries about 121 generic drugs from community pharmacies over a 3-year period (from July 2014 to June 2017) were analyzed.
RESULTS
RESULTS
Approximately 30% of the requests were related to the efficacy, safety, and comfort of the generic drug. The most cited motive was "patient's desire with no reason given" at 44.5%. According to multiple logistic regression analysis, therapeutic categories and dosage forms were associated with the requests. The median request frequency differed according to therapeutic category and dosage form. The frequency was highest for "agents affecting the central nervous system" and "tablets and capsules", respectively. Among the therapeutic categories, "agents affecting the central nervous system" had the highest median number of requests related to "decreased effectiveness"; "cardiovascular agents" had the highest median number of requests related to "physician's instruction"; and "agents for the epidermis" had the highest median number of requests related to "uncomfortable to use". Among dosage forms, the odds ratio for patients' original drug request for "liniment and patch" was about 1.5 times that for "tablets and capsules". "Liniment and patch" had the highest median frequency of requests related to "decreased effectiveness", "uncomfortable to use", and "patient's desire with no reason given".
CONCLUSIONS
CONCLUSIONS
The request frequency and reason differed according to therapeutic category and dosage form. Pharmacists should advise each patient properly about the choice and switching of drug brands, taking into account the therapeutic category and dosage form, especially liniments and patches.
Identifiants
pubmed: 33292744
doi: 10.1186/s40780-020-00180-w
pii: 10.1186/s40780-020-00180-w
pmc: PMC7716439
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27Références
Med Care. 2007 Feb;45(2):109-15
pubmed: 17224772
Ann Pharmacother. 2011 Jan;45(1):31-8
pubmed: 21205953
Health Policy. 2012 Jan;104(1):61-8
pubmed: 22024369
JAMA. 2008 Dec 3;300(21):2514-26
pubmed: 19050195
Res Social Adm Pharm. 2018 Jul;14(7):619-627
pubmed: 28814375
Health Policy. 2015 Nov;119(11):1406-14
pubmed: 26477667
J Manag Care Spec Pharm. 2018 Mar;24(3):252-264
pubmed: 29485953
J Gen Intern Med. 2007 Sep;22(9):1298-304
pubmed: 17647066
Pharm World Sci. 2008 Oct;30(5):590-4
pubmed: 18704749
Health Policy. 2011 Jan;99(1):60-5
pubmed: 20685003
BMC Med Inform Decis Mak. 2013 Oct 07;13:115
pubmed: 24099099
Int J Pharm Pract. 2009 Apr;17(2):79-88
pubmed: 20214255
Drugs. 2010 Mar 26;70(5):605-21
pubmed: 20329806
Fam Med. 2009 Feb;41(2):82-3
pubmed: 19184678
Patient Educ Couns. 2008 Nov;73(2):377-83
pubmed: 18706784
Eur J Clin Pharmacol. 2017 Apr;73(4):471-477
pubmed: 28035437
Drug Discov Ther. 2017 Jan 15;10(6):300-306
pubmed: 27725574
Neurology. 2008 May 27;70(22 Pt 2):2179-86
pubmed: 18505997
Pharm World Sci. 2006 Oct;28(5):284-9
pubmed: 17111247
BMC Health Serv Res. 2018 Nov 12;18(1):850
pubmed: 30419890
Bull World Health Organ. 2020 Mar 1;98(3):188-197K
pubmed: 32132753
Epilepsia. 2007 Mar;48(3):464-9
pubmed: 17346246
Eur J Epidemiol. 2016 Apr;31(4):351-68
pubmed: 26620809
Eur J Clin Pharmacol. 2013 Oct;69(10):1827-36
pubmed: 23765409
Drug Discov Ther. 2015 Jun;9(3):229-33
pubmed: 26193946