Evaluation of skin phototoxicity of transdermally administered pharmaceuticals in Sprague-Dawley rats.
Histopathology
In vivo test
Phototoxicity
Skin reaction
Transdermal
Journal
Laboratory animal research
ISSN: 1738-6055
Titre abrégé: Lab Anim Res
Pays: England
ID NLM: 101560684
Informations de publication
Date de publication:
19 Nov 2020
19 Nov 2020
Historique:
received:
13
08
2020
accepted:
03
11
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
10
12
2020
Statut:
epublish
Résumé
Some drugs cause phototoxicity in humans when exposed to light, thus there is a need for an in vivo phototoxicity test to evaluate them. However, an in vivo phototoxicity test method to evaluate this has not been established. This study aimed to establish an in vivo phototoxicity test method for transdermally administered drugs. For this, we evaluated the phototoxicity using Sprague-Dawley (SD) rats for transdermal administered drugs and we studied the appropriate UVA dose using 8-methoxypsalen, which is a well-known phototoxic drug. We found that a UVA dose of 15 J/cm
Identifiants
pubmed: 33292792
doi: 10.1186/s42826-020-00074-w
pii: 10.1186/s42826-020-00074-w
pmc: PMC7678087
doi:
Types de publication
Journal Article
Langues
eng
Pagination
42Subventions
Organisme : National Institute of Food and Drug Safety Evaluation
ID : 17181MFDS402
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