A review of burn symptoms and potential novel neural targets for non-invasive brain stimulation for treatment of burn sequelae.
Non-invasive brain stimulation
Pain
Pruritus
Psychosocial disorders
Transcranial direct current stimulation
Journal
Burns : journal of the International Society for Burn Injuries
ISSN: 1879-1409
Titre abrégé: Burns
Pays: Netherlands
ID NLM: 8913178
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
16
10
2019
revised:
30
04
2020
accepted:
06
06
2020
pubmed:
10
12
2020
medline:
10
11
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
Burn survivors experience myriad associated symptoms such as pain, pruritus, fatigue, impaired motor strength, post-traumatic stress, depression, anxiety, and sleep disturbance. Many of these symptoms are common and remain chronic, despite current standard of care. One potential novel intervention to target these post burn symptoms is transcranial direct current stimulation (tDCS). tDCS is a non-invasive brain stimulation (NIBS) technique that modulates neural excitability of a specific target or neural network. The aim of this work is to review the neural circuits of the aforementioned clinical sequelae associated with burn injuries and to provide a scientific rationale for specific NIBS targets that can potentially treat these conditions. We ran a systematic review, following the PRISMA statement, of tDCS effects on burn symptoms. Only three studies matched our criteria. One was a feasibility study assessing cortical plasticity in chronic neuropathic pain following burn injury, one looked at the effects of tDCS to reduce pain anxiety during burn wound care, and one assessed the effects of tDCS to manage pain and pruritus in burn survivors. Current literature on NIBS in burn remains limited, only a few trials have been conducted. Based on our review and results in other populations suffering from similar symptoms as patients with burn injuries, three main areas were selected: the prefrontal region, the parietal area and the motor cortex. Based on the importance of the prefrontal cortex in the emotional component of pain and its implication in various psychosocial symptoms, targeting this region may represent the most promising target. Our review of the neural circuitry involved in post burn symptoms and suggested targeted areas for stimulation provide a spring board for future study initiatives.
Identifiants
pubmed: 33293156
pii: S0305-4179(20)30422-8
doi: 10.1016/j.burns.2020.06.005
pmc: PMC8685961
mid: NIHMS1718567
pii:
doi:
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
525-537Subventions
Organisme : ACL HHS
ID : 90DP0035
Pays : United States
Organisme : ACL HHS
ID : 90DP0055
Pays : United States
Organisme : ACL HHS
ID : 90DPBU0001
Pays : United States
Organisme : NCCDPHP CDC HHS
ID : U48 DP000055
Pays : United States
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
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