Lipid Droplet Nucleation.
lipid droplet biogenesis
membrane chemistry
membrane curvature
neutral lipids
phase transitions
seipin
Journal
Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
27
07
2020
revised:
11
11
2020
accepted:
12
11
2020
pubmed:
10
12
2020
medline:
15
12
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets, surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid metabolism and function in diverse biological processes. During the past decade, multidisciplinary approaches have shed light on LD assembly steps from the endoplasmic reticulum (ER): nucleation, growth, budding, and formation of a separate organelle. However, the molecular mechanisms underpinning these steps remain elusive. In this review, we focus on the nucleation step, defining where and how LD assembly is initiated. We present how membrane biophysical and physicochemical properties control this step and how proteins act on it to orchestrate LD biogenesis.
Identifiants
pubmed: 33293168
pii: S0962-8924(20)30231-2
doi: 10.1016/j.tcb.2020.11.006
pii:
doi:
Substances chimiques
Membrane Proteins
0
Phospholipids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
108-118Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.