Association Between Serum Iron Biomarkers and Breast Cancer.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
28
05
2020
revised:
10
08
2020
accepted:
03
12
2020
pubmed:
10
12
2020
medline:
4
1
2022
entrez:
9
12
2020
Statut:
ppublish
Résumé
Iron is both essential to life and potentially toxic at higher levels. Epidemiologic studies of iron and breast cancer are sparse, with substantial heterogeneity found in a recent meta-analysis. Evidence based on a comprehensive set of iron biomarkers and a large sample size could help clarify relationships between iron body stores and breast cancer risk. A case-cohort sample of 6,008 women, including 3,011 incident cases, has been followed for a median of 7.9 years. We estimated breast cancer HRs with Cox models, including age as the primary time scale and including in turn iron, ferritin, percent transferrin saturation, and their first principal component (PC) both as categorical (quartiles) and continuous measures. Adjusted HRs for the highest versus lowest quartiles of iron, ferritin, and transferrin saturation (95% confidence interval) were 1.06 (0.90-1.25), 1.03 (0.87-1.23), and 0.94 (0.80-1.12), respectively, and 1.06 (0.90-1.25) for the first principal component (PC). Associations were similar when follow-up time was restricted to ≤4 or >2 years. A study with one of the largest sample sizes to date and with all three measures of circulating iron, ferritin, and transferrin saturation does not support a strong association between elevated iron stores and breast cancer risk. Further investigation of low iron may be warranted. These results do not support a strong association between iron overload and breast cancer incidence.
Sections du résumé
BACKGROUND
Iron is both essential to life and potentially toxic at higher levels. Epidemiologic studies of iron and breast cancer are sparse, with substantial heterogeneity found in a recent meta-analysis. Evidence based on a comprehensive set of iron biomarkers and a large sample size could help clarify relationships between iron body stores and breast cancer risk.
METHODS
A case-cohort sample of 6,008 women, including 3,011 incident cases, has been followed for a median of 7.9 years. We estimated breast cancer HRs with Cox models, including age as the primary time scale and including in turn iron, ferritin, percent transferrin saturation, and their first principal component (PC) both as categorical (quartiles) and continuous measures.
RESULTS
Adjusted HRs for the highest versus lowest quartiles of iron, ferritin, and transferrin saturation (95% confidence interval) were 1.06 (0.90-1.25), 1.03 (0.87-1.23), and 0.94 (0.80-1.12), respectively, and 1.06 (0.90-1.25) for the first principal component (PC). Associations were similar when follow-up time was restricted to ≤4 or >2 years.
CONCLUSIONS
A study with one of the largest sample sizes to date and with all three measures of circulating iron, ferritin, and transferrin saturation does not support a strong association between elevated iron stores and breast cancer risk. Further investigation of low iron may be warranted.
IMPACT
These results do not support a strong association between iron overload and breast cancer incidence.
Identifiants
pubmed: 33293341
pii: 1055-9965.EPI-20-0715
doi: 10.1158/1055-9965.EPI-20-0715
pmc: PMC7867615
mid: NIHMS1653940
doi:
Substances chimiques
Biomarkers
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
422-425Subventions
Organisme : Intramural NIH HHS
ID : Z01 ES044005
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA ES102245
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA ES103066
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
Références
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pubmed: 24443403
Annu Rev Nutr. 2018 Aug 21;38:97-125
pubmed: 30130469
Environ Health Perspect. 2017 Dec 20;125(12):127003
pubmed: 29373861
BMC Cancer. 2019 Jun 6;19(1):543
pubmed: 31170936
BMC Cancer. 2017 Oct 23;17(1):692
pubmed: 29058598