Genomic Characterization of
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
05
05
2020
revised:
05
08
2020
accepted:
02
12
2020
pubmed:
10
12
2020
medline:
21
1
2022
entrez:
9
12
2020
Statut:
ppublish
Résumé
In contrast to recurrence after initial diagnosis of stage I-III breast cancer [recurrent metastatic breast cancer (rMBC)], Targeted DNA sequencing (OncoPanel) was prospectively performed on either primary or metastatic tumors from 926 patients (212 dnMBC and 714 rMBC). Single-nucleotide variants, copy-number variations, and tumor mutational burden (TMB) in treatment-naïve dnMBC primary tumors were compared with primary tumors in patients who ultimately developed rMBC, and correlated with OS across all dnMBC. When comparing primary tumors by subtype, Genomic differences between treatment-naïve dnMBC and primary tumors of patients who developed rMBC may provide insight into mechanisms underlying metastatic potential and differential therapeutic sensitivity in dnMBC. Alterations associated with poor OS in dnMBC highlight the need for novel approaches to overcome potential intrinsic resistance to current treatments.
Identifiants
pubmed: 33293374
pii: 1078-0432.CCR-20-1720
doi: 10.1158/1078-0432.CCR-20-1720
pmc: PMC7887078
mid: NIHMS1653483
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Comparative Study
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1105-1118Subventions
Organisme : NCI NIH HHS
ID : P50 CA168504
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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