Mild hyperlipidemia in mice aggravates platelet responsiveness in thrombus formation and exploration of platelet proteome and lipidome.

Animals Apolipoproteins E / genetics Blood Platelets / chemistry Cholesterol / blood Disease Models, Animal Female Gene Knockout Techniques Hyperlipidemias / blood Lipidomics / methods Male Mice Platelet Activation Proteomics / methods Receptors, LDL / genetics Thrombosis / blood

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
08 12 2020
Historique:
received: 11 09 2020
accepted: 23 11 2020
entrez: 9 12 2020
pubmed: 10 12 2020
medline: 25 3 2021
Statut: epublish

Résumé

Hyperlipidemia is a well-established risk factor for cardiovascular diseases. Millions of people worldwide display mildly elevated levels of plasma lipids and cholesterol linked to diet and life-style. While the prothrombotic risk of severe hyperlipidemia has been established, the effects of moderate hyperlipidemia are less clear. Here, we studied platelet activation and arterial thrombus formation in Apoe

Identifiants

DOI: 10.1038/s41598-020-78522-9 PMID: 33293576 PMC: PMC7722935
pubmed: 33293576
doi: 10.1038/s41598-020-78522-9
pii: 10.1038/s41598-020-78522-9
pmc: PMC7722935
doi:

Substances chimiques

Apoe protein, mouse 0
Apolipoproteins E 0
Receptors, LDL 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

21407

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Auteurs

Johanna P van Geffen (JP)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Frauke Swieringa (F)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
Leibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.

Kim van Kuijk (K)

Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.

Bibian M E Tullemans (BME)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Fiorella A Solari (FA)

Leibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.

Bing Peng (B)

Leibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.

Kenneth J Clemetson (KJ)

Department of Haematology, Inselspital, University of Bern, Bern, Switzerland.

Richard W Farndale (RW)

Department of Biochemistry, University of Cambridge, Cambridge, UK.

Ludwig J Dubois (LJ)

The M-Lab, Department of Precision Medicine, School for Oncology and Developmental Biology (GROW), Maastricht University, Maastricht, The Netherlands.

Albert Sickmann (A)

Leibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.

René P Zahedi (RP)

Leibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.
Segal Cancer Proteomics Centre, Jewish General Hospital, McGill University, Montreal, Canada.

Robert Ahrends (R)

Leibniz Institut für Analytische Wissenschaften - ISAS- e.V, Dortmund, Germany.
Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Wien, Austria.

Erik A L Biessen (EAL)

Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.
Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany.

Judith C Sluimer (JC)

Department of Pathology, CARIM, Maastricht University, Maastricht, The Netherlands.
BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.

Johan W M Heemskerk (JWM)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.

Marijke J E Kuijpers (MJE)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands. Marijke.Kuijpers@maastrichtuniversity.nl.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Plaquettes › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-out de gènes › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles du métabolisme lipidique › Dyslipidémies › Hyperlipidémies › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Lipidomique › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hémostase › Activation plaquettaire › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux lipoprotéines › Récepteurs aux lipoprotéines LDL › Mild hyperlipidemia in mice aggravates...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Embolie et thrombose › Thrombose › Mild hyperlipidemia in mice aggravates...