Impact of Supporting People with Advanced Parkinson's Disease on Carer's Quality of Life and Burden.

advanced Parkinson’s disease caregiver burden intestinal infusion levodopa/carbidopa quality of life; QoL

Journal

Neuropsychiatric disease and treatment
ISSN: 1176-6328
Titre abrégé: Neuropsychiatr Dis Treat
Pays: New Zealand
ID NLM: 101240304

Informations de publication

Date de publication:
2020
Historique:
received: 04 04 2020
accepted: 01 10 2020
entrez: 9 12 2020
pubmed: 10 12 2020
medline: 10 12 2020
Statut: epublish

Résumé

The aim of this study was to assess the burden and the quality of life (QoL) perceived by caregivers assisting advanced Parkinson's disease (PD) patients. Consecutive advanced PD patients treated with levodopa/carbidopa intestinal gel (LCIG) or continuous subcutaneous apomorphine infusion (CSAI) or care as usual (CU) and their care partners were recruited during routine visits according to a cross-sectional design. Caregiver's distress was assessed by Zarit Burden Interview (ZBI) and a QoL survey to evaluate and understand the burden experienced by care partners during family and working activities. A total of 126 patients (53 LCIG, 19 CSAI and 54 CU) and their care partners were enrolled. The ZBI score boxplot showed that LCIG and CU populations have a similar distribution (ZBI inter-quartile range [IQR] values respectively 18-42 for LCIG and 19-43 for CU group), while the CSAI group has a wider score range (IQR 16-52). Caregivers assisting patients in treatment with LCIG have more time to perform family or household duties (p=0.0022), or to engage in leisure activities (p=0.0073) compared to CU, while no difference was found when compared to CSAI group. Approximately 50% of the care partners showed mood changes in the last 6 months and LCIG and CSAI had less impact on caregiver's mood compared to CU. Patients treated with LCIG were more independent in taking a bath or shower without assistance and were more able to move and walk without assistance. Care partners of advanced PD patients treated with device-aided therapies have more time for their own life and a better perception of their QoL with a tendency to an improvement of mood compared with those of patients treated with CU.

Identifiants

pubmed: 33293815
doi: 10.2147/NDT.S256217
pii: 256217
pmc: PMC7719333
doi:

Types de publication

Journal Article

Langues

eng

Pagination

2899-2912

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2020 Modugno et al.

Déclaration de conflit d'intérêts

N. Modugno reports fees for oral presentations from AbbVie, UCB, Zambon and Bial. A. Antonini has received compensation for consultancy and speaker related activities from UCB, Boehringer Ingelheim, AbbVie, Zambon, Bial, Ever Pharma, Neuroderm, Therevance, Biogen; he receives research support from Chiesi Pharmaceuticals, Lundbeck, Horizon 2020 - PD_Pal Grant 825,785, Ministry of Education University and Research (MIUR) Grant ARS01_01081. He serves as consultant for Boehringer–Ingelheim for legal cases on pathological gambling”. A. Tessitore declares speaking honoraria and travel expenses for attending meetings from AbbVie. P. Marano declares consultancy fees from AbbVie. F.E. Pontieri received honoraria for speaker activity from Zambon, AbbVie, Bial, compensation for serving in the Steering Committee of an international grant from AbbVie; he also received an unconditioned grant for research activity from Zambon. N. Tambasco received speaker honoraria from Lundbeck and AbbVie. M. Canesi declares grants from UCB, Zambon and Ralpharma. G. Fabbrini received payment for International Congress from Zambon; he is also the editorial board for Parkinsonism and Related Disorders. R. Quatrale has received honoraria for consulting services and symposia from AbbVie and Zambon. P. Solla has received honoraria for participation in advisory boards from AbbVie. G. Gualberti, G. Melzi, are employees of AbbVie Italy and may own AbbVie stocks/options. The other authors report no conflicts of interest in this work.

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Auteurs

Nicola Modugno (N)

Neurology Unit, IRCCS Neuromed, Pozzilli, Italy.

Angelo Antonini (A)

Parkinson and Movement Disorder Unit, Department of Neuroscience, University of Padua, Padua, Italy.

Alessandro Tessitore (A)

Department of Medical and Surgery Sciences, University of Campania, "Luigi Vanvitelli", Naples, Italy.

Pietro Marano (P)

Casa di Cura Madonna del Rosario, Raggruppamento di Riabilitazione, Catania, Italy.

Francesco Ernesto Pontieri (FE)

Department NESMOS, "Sapienza" University, Sant'Andrea Hospital, Roma, Italy.
IRCCS Fondazione Santa Lucia, Roma, Italy.

Nicola Tambasco (N)

Department of Neurology, Perugia General Hospital and University of Perugia, Perugia, Italy.

Margherita Canesi (M)

Dipartimento di Riabilitazione Malattia di Parkinson e Disordini del Movimento, Gravi Cerebrolesioni Acquisite, Italia Hospital - Ospedale "Moriggia-Pelascini", Gravedona ed Uniti, Como, Italy.
Centro Parkinson e Disordini del Movimento, CTO, G Pini, Milano, Italy.

Giovanni Fabbrini (G)

Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
IRCCS Neuromed, Pozzilli, Isernia, Italy.

Mariachiara Sensi (M)

Neurology Unit, Hospital Sant'Anna, Ferrara, Italy.

Rocco Quatrale (R)

Neurology Unit, Hospital dell'Angelo, Mestre, VE, Italy.

Paolo Solla (P)

Neurology Unit, Policlinico Universitario Monserrato, Cagliari, Italy.

Giovanni Defazio (G)

Neurology Unit, Policlinico Universitario Monserrato, Cagliari, Italy.

Gabriella Melzi (G)

Medical Department, AbbVie Srl, Roma, Italy.

Giuliana Gualberti (G)

Medical Department, AbbVie Srl, Roma, Italy.

Leonardo Lopiano (L)

Department of Neuroscience "Rita Levi Montalcini" University of Torino, Azienda Ospedaliero-Universitaria Città Della Salute e Della Scienza di Torino, Torino, Italy.

Classifications MeSH