Differences in pulmonary group 2 innate lymphoid cells are dependent on mouse age, sex and strain.
group 2 innate lymphoid cells (ILC2)
infant
innate lymphoid cells (ILC)
lung
neonate
respiratory
Journal
Immunology and cell biology
ISSN: 1440-1711
Titre abrégé: Immunol Cell Biol
Pays: United States
ID NLM: 8706300
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
02
12
2020
received:
23
10
2020
accepted:
06
12
2020
pubmed:
10
12
2020
medline:
29
9
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
Innate lymphoid cells (ILCs) are resident in the lung and are involved in both the maintenance of homeostasis and the pathogenesis of respiratory diseases. In this study, murine lung ILCs were characterized using flow cytometry and the impact of mouse age, sex and strain were assessed. Lung ILCs were found as early as postnatal day 4 and numbers peaked at 2 weeks, and then decreased as the lung matured. During postnatal lung development, ILC expressed differential amounts of group 2 ILC (ILC2)-associated cell surface antigens including ST2, CD90.2 and ICOS. Using Il5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
542-551Informations de copyright
© 2021 Australian and New Zealand Society for Immunology, Inc.
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