Medicine misuse: A systematic review and proposed hierarchical terminology.
appropriateness
drug misuse
hierarchical classification
real-world evidence
Journal
British journal of clinical pharmacology
ISSN: 1365-2125
Titre abrégé: Br J Clin Pharmacol
Pays: England
ID NLM: 7503323
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
revised:
25
09
2020
received:
09
06
2020
accepted:
05
10
2020
pubmed:
10
12
2020
medline:
27
7
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
Although medicine misuse is a public health issue, it has multiple meanings in the medical literature. This study aimed to characterize, classify and identify the most appropriate definitions of medicine misuse. A systematic review was performed in Medline, ISI Web of Science, SocINDEX, PsycInfo, PsycArticles and Psychological and Behavioral Sciences Collection, using keywords related to "misuse", "appropriateness" and "medicine" between 1 November 2008 and 25 August 2020. Additional searches were conducted in websites of regulatory agencies and public health institutions. Two authors independently selected studies providing both definitions and examples of misuse, while a third resolved disagreements. Definitions were used to propose a hierarchical classification based on initiator, intent, purpose and context of medicine misuse. The study is registered on PROSPERO: CRD42018115789. Of 3404 identified records, 51 were included. A total of 71 definitions and 74 examples of misuse were retrieved. When the prescriber is initiator and according to intent, potential medicine misuse referred to "intentional or unintentional prescribing not in line with clinical evidence". Based on context, they could prescribe medicines not clinically justified, i.e. overprescribing, or prescribe indicated medicines incorrectly, i.e. misprescribing. Among other groups of definitions, those overlapping with drug abuse or medication use errors were considered out-of-scope. This systematic review provides a comprehensive overview of the terms and definitions used to characterize medicine misuse and could serve as a basis for a terminology that makes clear distinctions between misuse, abuse and errors.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1695-1704Subventions
Organisme : Ministère de l'Enseignement Supérieur et de la Recherche
Organisme : PIA 3 (Investments for the Future)
ID : 17-EURE-0019
Informations de copyright
© 2020 British Pharmacological Society.
Références
Public Health England. Dependence and Withdrawal Associated with Some Prescribed Medicines: An Evidence Review.; 2019.
Center for Behavioral Health Statistics and Quality. 2017 National Survey on Drug Use and Health: Detailed Tables.; 2018.
Bégaud B, Costagliola D. Rapport Sur La Surveillance et La Promotion Du Bon Usage Du Médicament En France.; 2013.
Carey CM, Jena AB, Barnett ML. Patterns of Potential Opioid Misuse and Subsequent Adverse Outcomes in Medicare, 2008 to 2012. Ann Intern Med. 2018;168(12):837-845. https://doi.org/10.7326/M17-3065
Barrett SP, Meisner JR, Stewart SH. What constitutes prescription drug misuse? Problems and pitfalls of current conceptualizations. Curr Drug Abuse Rev. 2008;1(3):255-262. https://doi.org/10.2174/1874473710801030255
Smith SM, Dart RC, Katz NP, et al. Classification and definition of misuse, abuse, and related events in clinical trials: ACTTION systematic review and recommendations. Pain. 2013;154(11):2287-2296. https://doi.org/10.1016/j.pain.2013.05.053
Holloway KA. Combating inappropriate use of medicines. Expert Rev Clin Pharmacol. 2011;4(3):335-348. https://doi.org/10.1586/ecp.11.14
Thomas F, Depledge M. Medicine “misuse”: Implications for health and environmental sustainability. Soc Sci Med. 2015;143:81-87. https://doi.org/10.1016/j.socscimed.2015.08.028
Brady KT, Mccauley JL, Back SE. Prescription Opioid Misuse, Abuse, and Treatment in the United States: An Update. Am J Psychiatry. 2016;173(1):18-26. https://doi.org/10.1176/appi.ajp.2015.15020262
Maree RD, Marcum ZA, Saghafi E, Weiner DK, Karp JF. A Systematic Review of Opioid and Benzodiazepine Misuse in Older Adults. Am J Geriatr Psychiatry. 2016;24(11):949-963. https://doi.org/10.1016/j.jagp.2016.06.003
Hemsing N, Greaves L, Poole N, Schmidt R. Misuse of Prescription Opioid Medication among Women: A Scoping Review. Pain Res Manag. 2016:1-8. https://doi.org/10.1155/2016/1754195
Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. https://doi.org/10.1136/BMJ.B2535
Casati A, Sedefov R, Pfeiffer-Gerschel T. Misuse of medicines in the European Union: a systematic review of the literature. Eur Addict Res. 2012;18(5):228-245. https://doi.org/10.1159/000337028
Green J. Misuse and Abuse of Loperamide in the United States - Protocol.; 2016. http://www.encepp.eu/encepp/openAttachment/fullProtocol/16930
Larance B, Degenhardt L, Lintzeris N, Winstock A, Mattick R. Definitions related to the use of pharmaceutical opioids: extramedical use, diversion, non-adherence and aberrant medication-related behaviours. Drug Alcohol Rev. 2011;30(3):236-245. https://doi.org/10.1111/j.1465-3362.2010.00283.x
Lofwall M. A Review & Perspectives on Buprenorphine Diversion and Misuse: Implications for Policy and Practice.
Mccabe SE, West BT, Boyd CJ. Motives for Medical Misuse of Prescription Opioids among Adolescents. J Pain. 2013;14(10):1208-1216. https://doi.org/10.1016/j.jpain.2013.05.004
Mokhar A, Topp J, Härter M, et al. Patient-centered care interventions to reduce the inappropriate prescription and use of benzodiazepines and z-drugs: a systematic review. PeerJ. 2018;6:e5535. https://doi.org/10.7717/peerj.5535
Opondo D, Eslami S, Visscher S, et al. Inappropriateness of Medication Prescriptions to Elderly Patients in the Primary Care Setting: A Systematic ReviewSimpson C, ed. PLoS ONE. 2012;7(8):e43617. https://doi.org/10.1371/journal.pone.0043617
Panes A, Pariente A, Bénard-Laribière A, et al. Use of benzodiazepines and z-drugs not compliant with guidelines and associated factors: a population-based study. Eur Arch Psychiatry Clin Neurosci. 2020;270(1):3-10. https://doi.org/10.1007/s00406-018-0966-3
Reimer J, Wright N, Somaini L, et al. The impact of misuse and diversion of opioid substitution treatment medicines: Evidence review and expert consensus. Eur Addict Res. 2016;22(2):99-106. https://doi.org/10.1159/000438988
Rolland B, Bouhassira D, Authier N, et al. Mésusage et dépendance aux opioïdes de prescription: prévention, repérage et prise en charge. La Rev Med interne. 2017;38(8):539-546. https://doi.org/10.1016/j.revmed.2016.12.024
Schepis TS, Teter CJ, McCabe SE. Prescription drug use, misuse and related substance use disorder symptoms vary by educational status and attainment in U.S adolescents and young adults. Drug Alcohol Depend. 2018;189:172-177. https://doi.org/10.1016/j.drugalcdep.2018.05.017
Spinewine A, Schmader KE, Barber N, et al. Appropriate prescribing in elderly people: how well can it be measured and optimised? Lancet. 2007;370(9582):173-184. https://doi.org/10.1016/S0140-6736(07)61091-5
Weyandt LL, Oster DR, Marraccini ME, et al. Prescription stimulant medication misuse: Where are we and where do we go from here? Exp Clin Psychopharmacol. 2016;24(5):400-414. https://doi.org/10.1037/pha0000093
Wright N, D'Agnone O, Krajci P, et al. Addressing misuse and diversion of opioid substitution medication: guidance based on systematic evidence review and real-world experience. J Public Health (Oxf). 2016;38(3):e368-e374. https://doi.org/10.1093/pubmed/fdv150
Hartrick CT, Gatchel RJ, Conroy S. Identification and management of pain medication abuse and misuse: current state and future directions. Expert Rev Neurother. 2012;12(5):601-610. https://doi.org/10.1586/ern.12.34
ANSM. Bonnes Pratiques de Pharmacovigilance.; 2018. 2018. www.ansm.sante.fr
Blanco C, Han B, Jones CM, Johnson K, Compton. Prevalence and Correlates of Benzodiazepine Use, Misuse, and Use Disorders Among Adults in the United States. J Clin Psychiatry. 2018;79(6):e1-e10. https://doi.org/10.4088/JCP.18m12174
EMA. Guideline on Good Pharmacovigilance Practices (GVP) - Annex I - Definitions (Rev 3).; 2014. 2018. www.ema.europa.eu
FDA - Center for Drug Evaluation and Research. Abuse-Deterrent Opioids-Evaluation and Labeling.; 2015. http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/default.htm
FDA - Center for Drug Evaluation and Research. Joint Meeting of the Anesthetic and Analgesic Drug Products Advisory Committee, the Drug Safety and Risk Management Advisory Committee, and the Pediatric Advisory Committee Meeting.; 2016. https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AnestheticAndAnalgesicDrugProductsAdvisoryCommittee/UCM519723.pdf
FDA - Center for Drug Evaluation and Research. Joint Meeting of the Drug Safety and Risk Management (DSaRM) Advisory Committee and the Anesthetic and Analgesic Drug Products Advisory Committee (AADPAC).; 2016. https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AnestheticAndAnalgesicDrugProductsAdvisoryCommittee/UCM497290.pdf
FDA - Center for Drug Evaluation and Research. Joint Meeting of Anesthetic and Analgesic Drug Products Advisory Committee and Drug Safety and Risk Management Advisory Committee.; 2018. https://www.fda.gov/downloads/AdvisoryCommittees/CommitteesMeetingMaterials/Drugs/AnestheticAndAnalgesicDrugProductsAdvisoryCommittee/UCM596199.pdf
Han B, Compton WM, Blanco C, Crane E, Lee J, Jones CM. Prescription Opioid Use, Misuse, and Use Disorders in U.S. Adults: 2015 National Survey on Drug Use and Health. Ann Intern Med. 2017;167(5):293-301. https://doi.org/10.7326/M17-0865
HAS. Outils de Sécurisation et d'auto-Évaluation de l'administration Des Médicaments.; 2013. www.has-sante.fr
Holloway K, van Dijk L. The World Medicines Situation 2011: Rational Use of Medicines.; 2011. https://www.who.int/medicines/areas/policy/world_medicines_situation/WMS_ch14_wRational.pdf
Commonwealth of Australia. National Pharmaceutical Drug Misuse Framework for Action (2012-2015). 2012. http://www.nationaldrugstrategy.gov.au/internet/drugstrategy/Publishing.nsf/content/9C52D7D6E2C14A72CA257C3F001F009D/$File/NationalPDMFramework.pdf
NIDA. Misuse of Prescription Drugs.; 2018. https://www.drugabuse.gov
TGA. Pharmacovigilance Responsibilities of Medicine Sponsors - Australian Recommendations and Requirements.; 2018. https://www.tga.gov.au/book-page/your-regulatory-reporting-requirements
Winiecki SK. Understanding Abuse Deterrent Opioids. 2018. https://www.fda.gov/downloads/AboutFDA/WorkingatFDA/FellowshipInternshipGraduateFacultyPrograms/PharmacyStudentExperientialProgramCDER/UCM532123.pdf
Canada. Health Canada., Canada's Drug Strategy., W. Morrison & Associates., Gibson Library Connections. Best Practices: Treatment and Rehabilitation for Seniors with Substance Use Problems.; 2008. https://www.canada.ca/content/dam/hc-sc/migration/hc-sc/hc-ps/alt_formats/hecs-sesc/pdf/pubs/adp-apd/treat_senior-trait_ainee/treat_senior-trait_ainee-eng.pdf
Health Canada. Submission of targeted risk management plans and follow-up commitments for prescription opioid-containing products - Guidance for industry. Published 2018. https://www.canada.ca/en/health-canada/services/drugs-health-products/reports-publications/medeffect-canada/submission-targeted-rm-plans-commitments-prescription-opioid-containing-products-guidance-industry/document.html
Ministère des Solidarités et de la Santé. Mésusage. Published 2016. https://solidarites-sante.gouv.fr/soins-et-maladies/medicaments/glossaire/article/mesusage
Les cahiers de l'ordre national des pharmaciens. Cahier Thématique 7: Abus, Usage Récréatif, Addiction, Dopage… La Lutte Contre Le Mésusage Du Médicament. 2015. http://www.ordre.pharmacien.fr/content/download/218947/1249970/version/4/file/Cahier+th%C3%A9matique+7+-+La+lutte+contre+le+m%C3%A9susage+du+m%C3%A9dicament.pdf
Société Française de Pharmacie Clinique. Dictionnaire Français de l'erreur Médicamenteuse.; 2005. http://optimiz-sih-circ-med.fr/Documents/Dictionnaire_SFPC_EM.pdf
Allen HC, Garbe MC, Lees J, et al. Off-Label Medication use in Children, More Common than We Think: A Systematic Review of the Literature. J Okla State Med Assoc. 2018;111(8):776-783.
Hagemann V, Bausewein C, Remi C. Drug use beyond the licence in palliative care: A systematic review and narrative synthesis. Palliat Med. 2019;33(6):650-662. https://doi.org/10.1177/0269216319840602
Jaroszynski J, Mela A, Furtak-Niczyporuk M, et al. Off-Label Use Of Medicinal Products - Legal Rules And Practices. Acta Pol Pharm. 2019;76(4):621-628. https://doi.org/10.32383/appdr/105795
Peteet B, Mosley C, Miller-Roenigk B, McCuistian C, Dixon S. Transnational trends in prescription drug misuse among women: A systematic review. Int J Drug Policy. 2019;63:56-73. https://doi.org/10.1016/j.drugpo.2018.10.005
Schepis TS, Klare DL, Ford JA, McCabe SE. Prescription Drug Misuse: Taking a Lifespan Perspective. Subst Abus Res Treat. 2020;14:1-28. https://doi.org/10.1177/1178221820909352
Siste K, Nugraheni P, Christian H, Suryani E, Firdaus KK. Prescription drug misuse in adolescents and young adults: an emerging issue as a health problem. Curr Opin Psychiatry. 2019;32(4):320-327. https://doi.org/10.1097/YCO.0000000000000520
Yewale VN, Dharmapalan D. Promoting Appropriate Use of Drugs in Children. Int J Pediatr. 2012. https://doi.org/10.1155/2012/906570
Bénard-Laribière A, Noize P, Girodet P-O, et al. Monitoring of drug misuse or potential misuse in a nationwide healthcare insurance database: a cross-sectional study in France. Therapie. 2019;74(4):469-476. https://doi.org/10.1016/j.therap.2018.12.007
Blanchard J, Hunter SB, Osilla KC, Stewart W, Walters J, Pacula RL. A Systematic Review of the Prevention and Treatment of Prescription Drug Misuse. Mil Med. 2016;181(5):410-423. https://doi.org/10.7205/MILMED-D-15-00009
Aronson JK. Medication errors: Definitions and classification. Br J Clin Pharmacol. 2009;67(6):599-604. https://doi.org/10.1111/j.1365-2125.2009.03415.x
Ruiz M. Risks of Self-Medication Practices. Curr Drug Saf. 2010;5(4):315-323. https://doi.org/10.2174/157488610792245966
Hughes CM, Mcelnay JC, Fleming GF. The benefits and risks of self-medication. Drug Saf. 2001;24(14):1027-1037. https://doi.org/10.2165/00002018-200124140-00002
Makary MA, Overton HN, Wang P. Overprescribing is major contributor to opioid crisis. BMJ. 2017;359:j4792. https://doi.org/10.1136/bmj.j4792
Pérez T, Moriarty F, Wallace E, McDowell R, Redmond P, Fahey T. Prevalence of potentially inappropriate prescribing in older people in primary care and its association with hospital admission: longitudinal study. BMJ. 2018;363:k4524. https://doi.org/10.1136/bmj.k4524
Scott IA, Hilmer SN, Reeve E, et al. Reducing inappropriate polypharmacy: The process of deprescribing. JAMA Intern Med. 2015;175(5):827-834. https://doi.org/10.1001/jamainternmed.2015.0324