Castanea sativa Mill. bark extract cardiovascular effects in a rat model of high-fat diet.
cholinergic receptor
chronotropy
hydrolysable tannins
inotropy
oxydative stress
vascular relaxation
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
revised:
09
11
2020
received:
30
10
2019
accepted:
14
11
2020
pubmed:
10
12
2020
medline:
1
5
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
Ellagitannins may have a beneficial impact in cardiovascular diseases. The aim of the study was to evaluate the effect of high-fat diet (HFD) and the efficacy of Castanea sativa Mill. bark extract (ENC) on cardiac and vascular parameters. Rats were fed with regular diet, (RD, n = 15), HFD (n = 15), RD + ENC (20 mg/kg/day by gavage, n = 15), and HFD + ENC (same dose, n = 15) and the effects on body weight, biochemical serum parameters, and inflammatory cytokines determined. Cardiac functional parameters and aorta contractility were also assessed on isolated atria and aorta. Results showed that ENC reduced weight gain and serum lipids induced by HFD. In in vitro assays, HFD decreased the contraction force of left atrium, increased right atrium chronotropy, and decreased aorta K
Substances chimiques
Plant Extracts
0
Tannins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2145-2156Subventions
Organisme : RFO University of Bologna
Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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