COPD patients with chronic bronchitis and higher sputum eosinophil counts show increased type-2 and PDE4 gene expression in sputum.
Aged
Bronchitis, Chronic
/ blood
Cyclic Nucleotide Phosphodiesterases, Type 4
/ genetics
Eosinophils
/ pathology
Female
Gene Expression Profiling
Gene Expression Regulation
Gene Ontology
Gene Regulatory Networks
Humans
Inflammation
/ genetics
Leukocyte Count
Male
Placebos
Pulmonary Disease, Chronic Obstructive
/ blood
Reproducibility of Results
Sputum
/ cytology
chronic obstructive pulmonary disease
eosinophilic inflammation
phosphodiesterase 4 inhibitors
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
26
09
2020
accepted:
22
11
2020
pubmed:
10
12
2020
medline:
15
9
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
Chronic obstructive pulmonary disease (COPD) patients with higher eosinophil counts are associated with increased clinical response to phosphodiesterase-4-inhibitors (PDE4i). However, the underlying inflammatory mechanisms associated with this increased response is not yet elucidated. This post hoc analysis focused on sputum gene expression in patients with chronic bronchitis who underwent 32-day treatment with two doses of the inhaled PDE4i CHF6001 (tanimilast) or placebo on top of triple therapy. Biological characterization and treatment effects were assessed between patients with different sputum eosinophil levels (eosinophil
Identifiants
pubmed: 33295083
doi: 10.1111/jcmm.16146
pmc: PMC7812250
doi:
Substances chimiques
Placebos
0
Cyclic Nucleotide Phosphodiesterases, Type 4
EC 3.1.4.17
PDE4D protein, human
EC 3.1.4.17
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
905-918Subventions
Organisme : Chiesi Farmaceutici
Organisme : National Institute for Health Research (NIHR) Manchester Biomedical Research Centre (BRC)
Informations de copyright
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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