Scanning Protein Surfaces with DNA-Encoded Libraries.
DNA-encoded libraries
drug development
peptidomimetics
protein-protein interactions
screening
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
08 04 2021
08 04 2021
Historique:
received:
08
11
2020
pubmed:
10
12
2020
medline:
29
12
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
Understanding the ligandability of a target protein, defined as the capability of a protein to bind drug-like compounds on any site, can give important stimuli to drug-development projects. For instance, inhibition of protein-protein interactions usually depends on the identification of protein surface binders. DNA-encoded chemical libraries (DELs) allow scanning of protein surfaces with large chemical space. Encoded library selection screens uncovered several protein-protein interaction inhibitors and compounds binding to the surface of G protein-coupled receptors (GPCRs) and kinases. The protein surface-binding chemotypes from DELs are predominantly chemically modified and cyclized peptides, and functional small-molecule peptidomimetics. Peptoid libraries and structural peptidomimetics have been less studied in the DEL field, hinting at hitherto less populated chemical space and suggesting alternative library designs. Roughly a third of bioactive molecules evolved from smaller, target-focused libraries. They showcase the potential of encoded libraries to identify more potent molecules from weak, for example, fragment-like, starting points.
Identifiants
pubmed: 33295694
doi: 10.1002/cmdc.202000869
pmc: PMC8048995
doi:
Substances chimiques
Receptors, G-Protein-Coupled
0
Small Molecule Libraries
0
DNA
9007-49-2
Phosphotransferases
EC 2.7.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1048-1062Subventions
Organisme : DFG (Deutsche Forschungsgemeinschaft)
ID : BR 5049/7-1
Organisme : Mercator Research Center Ruhr (MERCUR)
ID : Pr-2016-0010
Organisme : Drug Discovery Hub Dortmund (DDHD)
Informations de copyright
© 2020 The Authors. ChemMedChem published by Wiley-VCH GmbH.
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