A selective effect of dopamine on information-seeking.
decision-making
dopamine
human
information-seeking
neuroscience
reward
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
02 12 2020
02 12 2020
Historique:
received:
20
05
2020
accepted:
16
11
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
2
4
2021
Statut:
epublish
Résumé
Humans are motivated to seek information from their environment. How the brain motivates this behavior is unknown. One speculation is that the brain employs neuromodulatory systems implicated in primary reward-seeking, in particular dopamine, to instruct information-seeking. However, there has been no causal test for the role of dopamine in information-seeking. Here, we show that administration of a drug that enhances dopamine function (dihydroxy-L-phenylalanine; L-DOPA) reduces the impact of valence on information-seeking. Specifically, while participants under Placebo sought more information about potential gains than losses, under L-DOPA this difference was not observed. The results provide new insight into the neurobiology of information-seeking and generates the prediction that abnormal dopaminergic function (such as in Parkinson's disease) will result in valence-dependent changes to information-seeking.
Identifiants
pubmed: 33295870
doi: 10.7554/eLife.59152
pii: 59152
pmc: PMC7725498
doi:
pii:
Substances chimiques
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Wellcome Trust
ID : 214268/Z/18/Z
Pays : United Kingdom
Informations de copyright
© 2020, Vellani et al.
Déclaration de conflit d'intérêts
VV, Ld, AG, TS No competing interests declared
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