Factors mediating the pressor response to isometric muscle contraction: An experimental study in healthy volunteers during lower body negative pressure.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
20
08
2020
accepted:
24
11
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
2
2
2021
Statut:
epublish
Résumé
Whilst both cardiac output (CO) and total peripheral resistance (TPR) determine mean arterial blood pressure (MAP), their relative importance in the pressor response to isometric exercise remains unclear. This study aimed to elucidate the relative importance of these two different factors by examining pressor responses during cardiopulmonary unloading leading to step-wise reductions in CO. Hemodynamics were investigated in 11 healthy individuals before, during and after two-minute isometric exercise during lower body negative pressure (LBNP; -20mmHg and -40mmHg). The blood pressure response to isometric exercise was similar during normal and reduced preload, despite a step-wise reduction in CO during LBNP (-20mmHg and -40mmHg). During -20mmHg LBNP, the decreased stroke volume, and consequently CO, was counteracted by an increased TPR, while heart rate (HR) was unaffected. HR was increased during -40 mmHg LBNP, although insufficient to maintain CO; the drop in CO was perfectly compensated by an increased TPR to maintain MAP. Likewise, transient application of LBNP (-20mmHg and -40mmHg) resulted in a short transient drop in MAP, caused by a decrease in CO, which was compensated by an increase in TPR. This study suggests that, in case of reductions of CO, changes in TPR are primarily responsible for maintaining the pressor response during isometric exercise. This highlights the relative importance of TPR compared to CO in mediating the pressor response during isometric exercise.
Identifiants
pubmed: 33296410
doi: 10.1371/journal.pone.0243627
pii: PONE-D-20-26181
pmc: PMC7725372
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0243627Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Circulation. 2003 Jun 24;107(24):3109-16
pubmed: 12821592
J Am Soc Hypertens. 2016 Jun;10(6):527-535.e2
pubmed: 27292824
J Physiol. 1993 Dec;472:501-12
pubmed: 8145156
J Physiol. 1966 Apr;183(3):607-27
pubmed: 5919559
J Physiol. 1967 Oct;192(3):595-607
pubmed: 6058995
Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H320-30
pubmed: 19966060
J Physiol. 1981 Sep;318:445-53
pubmed: 7320900
Am J Physiol. 1994 Aug;267(2 Pt 2):H593-604
pubmed: 8067416
Am J Physiol Regul Integr Comp Physiol. 2018 Jan 1;314(1):R114-R121
pubmed: 29070505
Med Biol Eng Comput. 1990 Nov;28(6):555-60
pubmed: 2287179
Am J Physiol Heart Circ Physiol. 2000 Mar;278(3):H818-28
pubmed: 10710350
J Physiol. 1990 Jul;426:423-37
pubmed: 2231406
Acta Physiol (Oxf). 2010 Nov;200(3):211-21
pubmed: 20456282
Hypertension. 1989 Jun;13(6 Pt 1):647-55
pubmed: 2500393
Annu Rev Med. 1974;25:369-81
pubmed: 4596232
Clin Exp Hypertens. 2020 Oct 2;42(7):595-600
pubmed: 32249609
J Appl Physiol (1985). 1988 May;64(5):2197-203
pubmed: 3391918
Circulation. 1974 Jun;49(6):1185-9
pubmed: 4598634
Eur J Appl Physiol. 2004 Mar;91(2-3):336-41
pubmed: 14595563
J Appl Physiol (1985). 1988 Oct;65(4):1752-6
pubmed: 3182536
Compr Physiol. 2017 Dec 12;8(1):103-151
pubmed: 29357126
Am J Physiol Heart Circ Physiol. 2018 Mar 1;314(3):H593-H602
pubmed: 29351473
J Sci Med Sport. 2017 Feb;20(2):196-201
pubmed: 27012728
Am J Physiol Heart Circ Physiol. 2014 Jan 15;306(2):H251-60
pubmed: 24213616
Am J Physiol Regul Integr Comp Physiol. 2001 Jul;281(1):R213-21
pubmed: 11404296
Circulation. 1988 Jul;78(1):49-59
pubmed: 3383410
Clin Sci (Lond). 1983 Jun;64(6):593-9
pubmed: 6839666
Clin Sci. 1964 Oct;27:229-44
pubmed: 14220903
Aviat Space Environ Med. 1994 Jul;65(7):615-20
pubmed: 7945128
Eur Radiol. 2016 Apr;26(4):1009-17
pubmed: 26205639
J Am Coll Cardiol. 1988 Nov;12(5):1241-51
pubmed: 3170967
J Clin Invest. 1974 Jul;54(1):104-15
pubmed: 4600046
J Physiol. 1987 Dec;393:499-512
pubmed: 3328782
Aviat Space Environ Med. 1986 Jun;57(6):531-8
pubmed: 3718376
J Appl Physiol (1985). 2007 Jul;103(1):228-33
pubmed: 17412786
Am J Hypertens. 2018 Feb 9;31(3):362-368
pubmed: 29036548
Acta Physiol (Oxf). 2009 Feb;195(2):289-300
pubmed: 18680560
J Appl Physiol (1985). 1993 May;74(5):2559-65
pubmed: 8335592
Am J Physiol Regul Integr Comp Physiol. 2001 Sep;281(3):R683-98
pubmed: 11506981
Acta Physiol (Oxf). 2012 Sep;206(1):51-61
pubmed: 22591110
Biom J. 2008 Jun;50(3):346-63
pubmed: 18481363
J Cardiovasc Nurs. 2003 Apr-Jun;18(2):116-23
pubmed: 12680570
Am J Physiol. 1998 Sep;275(3):H767-75
pubmed: 9724278
Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H215-23
pubmed: 16936003
J Physiol. 2000 May 15;525 Pt 1:253-62
pubmed: 10811741
Cardiology. 2007;107(2):103-6
pubmed: 16847387
Cardiovasc Res. 1990 Mar;24(3):214-21
pubmed: 2346955
Physiol Rev. 2019 Jan 1;99(1):807-851
pubmed: 30540225
Acta Physiol Scand. 1980 Jul;109(3):333-41
pubmed: 7446176
Aviat Space Environ Med. 1998 Jan;69(1):32-9
pubmed: 9451531
Int J Sports Med. 1991 Feb;12(1):41-5
pubmed: 2030058
J Physiol. 1937 Jun 3;89(4):372-83
pubmed: 16994867
Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1645-52
pubmed: 11247775
Am J Cardiol. 1988 Nov 15;62(16):1058-61
pubmed: 3189168
J Appl Physiol (1985). 2019 Aug 1;127(2):408-414
pubmed: 31219771
Auton Neurosci. 2020 Nov;228:102698
pubmed: 32861944
Eur J Appl Physiol Occup Physiol. 1993;66(5):381-7
pubmed: 8330604
Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1908-17
pubmed: 17616747
Aviat Space Environ Med. 2003 Aug;74(8):874-8
pubmed: 12924764
Eur J Appl Physiol. 2013 Jan;113(1):183-90
pubmed: 22644569