[Common cause and mechanism for all pathologies of aging?]
Cause commune et mécanisme commun aux maladies du vieillissement ?
Journal
Medecine sciences : M/S
ISSN: 1958-5381
Titre abrégé: Med Sci (Paris)
Pays: France
ID NLM: 8710980
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
26
1
2021
Statut:
ppublish
Résumé
Health is harmony, aging and its diseases (are) functional disharmony at the molecular, cellular and tissue levels. Our observations lead us to think that there seems to be a common cause and a common mechanism for aging and its many and diverse diseases. This common cause is the oxidative damage to particular proteins emerging from a combination of imperfect folding and oxidative stress. This common cause jointly goes with the biological clock common to various age-related diseases, whose the incidence increases exponentially over time and causes 90% of human mortality. Pharmacological interventions on the common cause could avoid and simultaneously attenuate all degenerative and malignant diseases, as it is the natural case of super-centenarians. Cause commune et mécanisme commun aux maladies du vieillissement ? La santé est l’harmonie, le vieillissement et ses maladies la dysharmonie fonctionnelle aux niveaux moléculaire, cellulaire et tissulaire. Nos observations semblent suggérer une cause commune et un mécanisme commun du vieillissement et de ses nombreuses et diverses maladies. Cette cause commune est le dommage oxydatif de protéines particulières, résultant à la fois de leur mauvais repliement et du stress oxydatif. La cause commune va de pair avec l’horloge biologique des diverses maladies du vieillissement, dont l’incidence augmente exponentiellement avec l’âge, responsables de 90 % de la mortalité humaine. Des interventions pharmacologiques sur la cause commune pourraient éviter et atténuer simultanément toutes les maladies dégénératives et malignes, comme c’est le cas naturellement chez les super-centenaires.
Autres résumés
Type: Publisher
(fre)
Cause commune et mécanisme commun aux maladies du vieillissement ?
Identifiants
pubmed: 33296629
doi: 10.1051/medsci/2020221
pii: msc200068
doi:
Types de publication
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
1129-1134Informations de copyright
© 2020 médecine/sciences – Inserm.
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