Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19.
COVID-19
SARS-CoV2
adaptive immune response
human
memory B cell
memory T cell
monoclonal antibody
vaccine
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
07 01 2021
07 01 2021
Historique:
received:
16
10
2020
revised:
04
11
2020
accepted:
17
11
2020
pubmed:
10
12
2020
medline:
16
1
2021
entrez:
9
12
2020
Statut:
ppublish
Résumé
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus is causing a global pandemic, and cases continue to rise. Most infected individuals experience mildly symptomatic coronavirus disease 2019 (COVID-19), but it is unknown whether this can induce persistent immune memory that could contribute to immunity. We performed a longitudinal assessment of individuals recovered from mild COVID-19 to determine whether they develop and sustain multifaceted SARS-CoV-2-specific immunological memory. Recovered individuals developed SARS-CoV-2-specific immunoglobulin (IgG) antibodies, neutralizing plasma, and memory B and memory T cells that persisted for at least 3 months. Our data further reveal that SARS-CoV-2-specific IgG memory B cells increased over time. Additionally, SARS-CoV-2-specific memory lymphocytes exhibited characteristics associated with potent antiviral function: memory T cells secreted cytokines and expanded upon antigen re-encounter, whereas memory B cells expressed receptors capable of neutralizing virus when expressed as monoclonal antibodies. Therefore, mild COVID-19 elicits memory lymphocytes that persist and display functional hallmarks of antiviral immunity.
Identifiants
pubmed: 33296701
pii: S0092-8674(20)31565-8
doi: 10.1016/j.cell.2020.11.029
pmc: PMC7682481
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Immunoglobulin G
0
Spike Glycoprotein, Coronavirus
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
169-183.e17Subventions
Organisme : NIAID NIH HHS
ID : R01 AI118803
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI106677
Pays : United States
Organisme : NIH HHS
ID : S10 OD024979
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK089507
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007140
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127726
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150178
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR002318
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI142001
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI151698
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI125378
Pays : United States
Commentaires et corrections
Type : UpdateOf
Type : UpdateOf
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests M.P., D.J.R., J.N., C.D.T., Y.C., and L.B.R. have filed a patent under the provisional serial no. 63/063,841. Other authors declare no competing interests.
Références
Nature. 2020 Aug;584(7819):120-124
pubmed: 32454512
Cell. 2020 Nov 25;183(5):1367-1382.e17
pubmed: 33160446
Cell. 2020 Oct 1;183(1):158-168.e14
pubmed: 32979941
Sci Transl Med. 2013 Mar 13;5(176):176ra32
pubmed: 23486778
Science. 2020 Dec 4;370(6521):1227-1230
pubmed: 33115920
Nat Protoc. 2009;4(3):372-84
pubmed: 19247287
Cell Rep. 2019 Apr 30;27(5):1446-1460.e4
pubmed: 31042472
Nat Rev Immunol. 2020 Aug;20(8):457-458
pubmed: 32636479
Science. 2020 Aug 14;369(6505):812-817
pubmed: 32434946
Nat Commun. 2021 May 19;12(1):2938
pubmed: 34011939
Clin Infect Dis. 2021 Nov 2;73(9):e2946-e2951
pubmed: 32840608
Emerg Infect Dis. 2007 Oct;13(10):1562-4
pubmed: 18258008
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
Nat Med. 2020 Sep;26(9):1428-1434
pubmed: 32661393
J Immunol. 2020 Aug 15;205(4):915-922
pubmed: 32591393
Immunity. 2011 Jan 28;34(1):108-21
pubmed: 21215658
Science. 1996 Apr 5;272(5258):54-60
pubmed: 8600537
J Immunol. 2011 Jun 15;186(12):7264-8
pubmed: 21576510
J Clin Microbiol. 2020 Oct 21;58(11):
pubmed: 32826322
Nat Med. 2020 Jul;26(7):1033-1036
pubmed: 32398876
Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5545-50
pubmed: 11960012
Cell. 2020 Jun 25;181(7):1489-1501.e15
pubmed: 32473127
Nature. 1999 Oct 14;401(6754):708-12
pubmed: 10537110
MMWR Morb Mortal Wkly Rep. 2020 Oct 30;69(43):1600-1604
pubmed: 33119558
Ann N Y Acad Sci. 1996 Oct 25;797:166-76
pubmed: 8993360
Immunity. 2009 Jan 16;30(1):92-107
pubmed: 19119024
Annu Rev Immunol. 2017 Apr 26;35:255-284
pubmed: 28142324
Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):E3216-24
pubmed: 23922396
Nat Med. 2020 Jun;26(6):845-848
pubmed: 32350462
Nat Microbiol. 2020 Dec;5(12):1598-1607
pubmed: 33106674
Sci Transl Med. 2020 Aug 5;12(555):
pubmed: 32690628
Annu Rev Immunol. 2016 May 20;34:335-68
pubmed: 26907215
Cell Rep. 2016 Dec 20;17(12):3193-3205
pubmed: 28009289
Immunity. 2020 Nov 17;53(5):925-933.e4
pubmed: 33129373
Cell Mol Immunol. 2020 Jul;17(7):773-775
pubmed: 32467617
Cell. 2020 Oct 1;183(1):143-157.e13
pubmed: 32877699
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
Methods Mol Biol. 2019;1956:105-125
pubmed: 30779032
Methods Mol Biol. 2012;882:569-604
pubmed: 22665256
Epidemiol Infect. 1990 Oct;105(2):435-46
pubmed: 2170159
Nat Biotechnol. 2020 Sep;38(9):1073-1078
pubmed: 32704169
PLoS One. 2017 Oct 24;12(10):e0186998
pubmed: 29065175
Immunity. 2016 Aug 16;45(2):402-14
pubmed: 27473412
Science. 2020 Sep 4;369(6508):
pubmed: 32669297
Cell Immunol. 2017 Nov;321:26-34
pubmed: 28739077
Front Immunol. 2018 Apr 09;9:678
pubmed: 29686673
Nature. 2020 Nov;587(7833):270-274
pubmed: 32726801
Nat Commun. 2020 Sep 4;11(1):4420
pubmed: 32887876
N Engl J Med. 2007 Nov 8;357(19):1903-15
pubmed: 17989383
Immunol Rev. 2019 Mar;288(1):149-160
pubmed: 30874358
Clin Vaccine Immunol. 2010 Jul;17(7):1055-65
pubmed: 20463105
Sci Immunol. 2020 Oct 8;5(52):
pubmed: 33033173
Clin Infect Dis. 2021 Oct 5;73(7):e1830-e1840
pubmed: 33315061
Nat Immunol. 2013 Apr;14(4):372-9
pubmed: 23475182
Annu Rev Immunol. 2016 May 20;34:317-34
pubmed: 27168241
Biochem J. 1960 Sep;76:475-87
pubmed: 13694426
JCI Insight. 2017 Apr 20;2(8):
pubmed: 28422752
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Annu Rev Immunol. 2020 Apr 26;38:705-725
pubmed: 32340571