Quercetin alleviates styrene oxide-induced cytotoxicity in cortical neurons

Apoptosis Caspase 3 / metabolism Epoxy Compounds / toxicity Humans Necrosis Neurons / drug effects Neuroprotective Agents / pharmacology Oxidative Stress Quercetin / pharmacology Reactive Oxygen Species / metabolism
Styrene oxide apoptosis necroptosis necrosis oxidative stress quercetin

Journal

Drug and chemical toxicology
ISSN: 1525-6014
Titre abrégé: Drug Chem Toxicol
Pays: United States
ID NLM: 7801723

Informations de publication

Date de publication:
Jul 2022
Historique:
pubmed: 11 12 2020
medline: 10 6 2022
entrez: 10 12 2020
Statut: ppublish

Résumé

Styrene 7,8-oxide (SO) is the principal metabolite of styrene, an industrial neurotoxic compound which causes various neurodegenerative disorders. The present study aimed to explore the mechanisms of SO cytotoxicity (0.5 - 4

Identifiants

DOI: 10.1080/01480545.2020.1851706 PMID: 33297769
pubmed: 33297769
doi: 10.1080/01480545.2020.1851706
doi:

Substances chimiques

Epoxy Compounds 0
Neuroprotective Agents 0
Reactive Oxygen Species 0
Quercetin 9IKM0I5T1E
styrene oxide 9QH06NGT6O
Caspase 3 EC 3.4.22.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1634-1643

Auteurs

Sabrine Moujahed (S)

Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, University of Carthage, Jarzouna, Tunisia.

Asier Ruiz (A)

Faculty of Medicine and Nursing, Department of Neurosciences, University of the Basque Country, Vizcaya, Spain.

Dorsaf Hallegue (D)

Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, University of Carthage, Jarzouna, Tunisia.

Mohsen Sakly (M)

Faculty of Sciences of Bizerte, Laboratory of Integrative Physiology, University of Carthage, Jarzouna, Tunisia.
ORCID: 0000-0001-8980-3712

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines régulatrices de l'apoptose › Caspases › Caspases effectrices › Caspase-3 › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › Composés chimiques organiques › Éthers › Composés époxy › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › Cellules › Neurones › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Quercétine › Quercetin alleviates styrene oxide-induced...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Quercetin alleviates styrene oxide-induced...