HDP-101, an Anti-BCMA Antibody-Drug Conjugate, Safely Delivers Amanitin to Induce Cell Death in Proliferating and Resting Multiple Myeloma Cells.


Journal

Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535

Informations de publication

Date de publication:
02 2021
Historique:
received: 10 04 2020
revised: 09 09 2020
accepted: 24 11 2020
pubmed: 11 12 2020
medline: 21 10 2021
entrez: 10 12 2020
Statut: ppublish

Résumé

Despite major treatment advances in recent years, patients with multiple myeloma inevitably relapse. The RNA polymerase II complex has been identified as a promising therapeutic target in both proliferating and dormant cancer cells. Alpha-amanitin, a toxin so far without clinical application due to high liver toxicity, specifically inhibits this complex. Here, we describe the development of HDP-101, an anti-B-cell maturation antigen (BCMA) antibody conjugated with an amanitin derivative. HDP-101 displayed high efficacy against both proliferating and resting myeloma cells

Identifiants

pubmed: 33298585
pii: 1535-7163.MCT-20-0287
doi: 10.1158/1535-7163.MCT-20-0287
doi:

Substances chimiques

Amanitins 0
Enzyme Inhibitors 0
Immunoconjugates 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

367-378

Informations de copyright

©2020 American Association for Cancer Research.

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Auteurs

Vianihuini Figueroa-Vazquez (V)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Jonathan Ko (J)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Christian Breunig (C)

Heidelberg Pharma Research GmbH, Ladenburg, Germany.

Anja Baumann (A)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Nicola Giesen (N)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Anikó Pálfi (A)

Heidelberg Pharma Research GmbH, Ladenburg, Germany.

Christoph Müller (C)

Heidelberg Pharma Research GmbH, Ladenburg, Germany.

Christian Lutz (C)

Heidelberg Pharma Research GmbH, Ladenburg, Germany.

Torsten Hechler (T)

Heidelberg Pharma Research GmbH, Ladenburg, Germany.

Michael Kulke (M)

Heidelberg Pharma Research GmbH, Ladenburg, Germany.

Carsten Müller-Tidow (C)

Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Alwin Krämer (A)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

Hartmut Goldschmidt (H)

Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.
National Center of Tumor Diseases (NCT), Heidelberg, Germany.

Andreas Pahl (A)

Heidelberg Pharma Research GmbH, Ladenburg, Germany. m.raab@dkfz.de andreas.pahl@hdpharma.com.

Marc S Raab (MS)

Clinical Cooperation Unit Molecular Hematology/Oncology, German Cancer Research Center (DKFZ) and Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany. m.raab@dkfz.de andreas.pahl@hdpharma.com.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.

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