Leukemia Cutis With Histopathologic and Immunophenotypic Features Resembling S100-Negative CD1a-Positive Cutaneous Histiocytosis.
Journal
The American Journal of dermatopathology
ISSN: 1533-0311
Titre abrégé: Am J Dermatopathol
Pays: United States
ID NLM: 7911005
Informations de publication
Date de publication:
01 Aug 2021
01 Aug 2021
Historique:
pubmed:
11
12
2020
medline:
21
12
2021
entrez:
10
12
2020
Statut:
ppublish
Résumé
S100-negative CD1a-positive cutaneous histiocytosis is an exceedingly rare histiocytosis that is defined histopathologically by a dense dermal infiltrate of ovoid mononuclear cells with grooved nuclei and ample cytoplasm with variable nuclear atypia and mitoses that are immunohistochemically positive for CD1a and negative for S100 and CD207 (langerin). The histogenesis of S100-negative CD1a-positive histiocytosis is unclear, and its precursor cell has yet to be characterized. Although all cases thus far have been described as benign and occasionally self-resolving, the clinical course and outcome of this disease are not fully understood. This case expands the spectrum of disease associated with S100-negative CD1a-positive histiocytosis given its malignant course.
Identifiants
pubmed: 33298709
pii: 00000372-202108000-00006
doi: 10.1097/DAD.0000000000001868
doi:
Substances chimiques
Antigens, CD1
0
CD1a antigen
0
S100 Proteins
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
574-575Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
Références
Emile JF, Abla O, Fraitag S, et al. Revised classification of histiocytoses and neoplasms of the macrophage-dendritic cell lineages. Blood . 2016;127:2672–2681.
Ventarola DJ, Mercer SE, Contard PC, et al. S-100-negative, CD1a-positive histiocytosis: a new variant with features of both indeterminate cells and interstitial dermal dendrocytes. Arch Dermatol. 2011;147:995–997.
Amin S, Jamerson J, Tee RG, et al. A case of S-100-negative CD1a-positive indeterminate cell histiocytosis. J Cutan Pathol. 2019;46:945–948.
Tardío JC, Aguado M, Borbujo J. Self-regressing S100-negative CD1a-positive cutaneous histiocytosis. Am J Dermatopathol. 2013;35:e57–e59.
Mask-Bull L, Crowson NA, John A, et al. S100-negative, CD1a-positive cutaneous histiocytosis in a patient with S100-positive, CD1a-positive pulmonary histiocytosis. Am J Dermatopathol. 2015;37:647–649.