BEX2 suppresses mitochondrial activity and is required for dormant cancer stem cell maintenance in intrahepatic cholangiocarcinoma.
Bile Duct Neoplasms
/ genetics
Carrier Proteins
/ genetics
Cell Cycle Proteins
/ genetics
Cell Line, Tumor
Cholangiocarcinoma
/ genetics
Cullin Proteins
/ genetics
Gene Expression Regulation, Neoplastic
Humans
Mitochondria
/ genetics
Neoplastic Stem Cells
/ metabolism
Nerve Tissue Proteins
/ genetics
Oxygen Consumption
/ physiology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 12 2020
09 12 2020
Historique:
received:
20
01
2020
accepted:
23
10
2020
entrez:
10
12
2020
pubmed:
11
12
2020
medline:
1
5
2021
Statut:
epublish
Résumé
Cancer stem cells (CSCs) define a subpopulation of cancer cells that are resistant to therapy. However, little is known of how CSC characteristics are regulated. We previously showed that dormant cancer stem cells are enriched with a CD274
Identifiants
pubmed: 33299012
doi: 10.1038/s41598-020-78539-0
pii: 10.1038/s41598-020-78539-0
pmc: PMC7725823
doi:
Substances chimiques
BEX2 protein, human
0
CUL2 protein, human
0
Carrier Proteins
0
Cell Cycle Proteins
0
Cullin Proteins
0
FEM1B protein, human
0
Nerve Tissue Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
21592Références
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