On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer.
Journal
NPJ precision oncology
ISSN: 2397-768X
Titre abrégé: NPJ Precis Oncol
Pays: England
ID NLM: 101708166
Informations de publication
Date de publication:
13 Nov 2020
13 Nov 2020
Historique:
received:
08
05
2020
accepted:
21
10
2020
entrez:
10
12
2020
pubmed:
11
12
2020
medline:
11
12
2020
Statut:
epublish
Résumé
We addressed a significant unknown feature of circulating tumor DNA (ctDNA), i.e., how ctDNA levels change during chemotherapy, by serially monitoring ctDNA in patients with colorectal cancer during the 48-h application of FOLFOX. Surprisingly, we did not observe a spike in ctDNA as a sign of a responsive tumor, but instead ctDNA levels initially decreased and remained low in patients with stable disease or partial response. Our observations reveal further insights into cell destruction during chemotherapy with important implications for the management of patients.
Identifiants
pubmed: 33299124
doi: 10.1038/s41698-020-00134-3
pii: 10.1038/s41698-020-00134-3
pmc: PMC7666126
doi:
Types de publication
Journal Article
Langues
eng
Pagination
30Subventions
Organisme : Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung)
ID : KLI 764
Organisme : Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung)
ID : KLI 710
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