Emerging data supporting stromal cell therapeutic potential in cancer: reprogramming stromal cells of the tumor microenvironment for anti-cancer effects.
Stromal cells
anti-cancer effects
reprogramming
tumor microenvironment
tumorigenic effects
Journal
Cancer biology & medicine
ISSN: 2095-3941
Titre abrégé: Cancer Biol Med
Pays: China
ID NLM: 101588850
Informations de publication
Date de publication:
15 11 2020
15 11 2020
Historique:
received:
24
03
2020
accepted:
20
08
2020
entrez:
10
12
2020
pubmed:
11
12
2020
medline:
30
11
2021
Statut:
ppublish
Résumé
After more than a decade of controversy on the role of stromal cells in the tumor microenvironment, the emerging data shed light on pro-tumorigenic and potential anti-cancer factors, as well as on the roots of the discrepancies. We discuss the pro-tumorigenic effects of stromal cells, considering the effects of tumor drivers like hypoxia and tumor stiffness on these cells, as well as stromal cell-mediated adiposity and immunosuppression in the tumor microenvironment, and cancer initiating cells' cellular senescence and adaptive metabolism. We summarize the emerging data supporting stromal cell therapeutic potential in cancer, discuss the possibility to reprogram stromal cells of the tumor microenvironment for anti-cancer effects, and explore some causes of discrepancies on the roles of stromal cells in cancer in the available literature.
Identifiants
pubmed: 33299638
doi: 10.20892/j.issn.2095-3941.2020.0133
pii: j.issn.2095-3941.2020.0133
pmc: PMC7721102
doi:
pii:
Types de publication
Journal Article
Review
Langues
eng
Pagination
828-841Informations de copyright
Copyright: © 2020, Cancer Biology & Medicine.
Déclaration de conflit d'intérêts
Conflict of interest statement No potential conflicts of interest are disclosed.
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